Respiratory Viruses 1 Flashcards
(44 cards)
how do viruses change so quickly
segmented genome recombination
orthomyxo viruses
influenza
paramyxo viruses
measles
mumps
parainfluenza (croup)
respiratory syncitial disease
what gives influenza subtypes
H and N types present on the surface
influenza type A
animals and humans
multiple subtypes
responsible for pandemics
constantly changing
influenza type B
humans only
no subtypes
properties of influenza
envelope helical 8 strands - RNA nucleus replication
infleunza HA does
attachment
influenza Na does
cuts through upper respiratory tract mucus
influenza transmission
person to person via small aerosolized droplets
antigenic drift
mutations in HA and NA surface antigens that allow for the virus to evade the immune system
what does antigenic drift
influenza A and B
what does antigenic shift
influenza A
antigenic shift
switching chunks of genetic material between subtypes
influenza incubation period
1-2 days
influenza infectious period
1 day prior to symptoms
2-6 days after symptoms end
antivirals for influenza A
amantadine
rimantadine
antivirals for influenza
oseltamivir
zanamivir- inhaled
MOA amantadine and rimantadine
blocks M2 protein ion channel and prevents endosome pH change –> blocks uncoating
MOA oseltamivir and zanamivir
block NA and prevent viral release
Reye’s syndrome
brain swelling and fatty degeneration of liver
Type B influenza complication giving febrile kids aspirin
influenza vaccine
live attenuated
inactivated
recombinant
(6 total)
paramyxo properties
envelop
helical
1 segment
- RNA
measles incubation period
14 days
