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Flashcards in Lung 2 Deck (34):
1

diffuse interstitial/restrictive disease

diffuse, chronic involvement of pulmonary interstitum reducing FEV1 and FVC

2

wheezing in restrictive disease?

NO- only in obstruction
no obstruction in restrictive

3

cause of diffuse interstitial disease

inhalation of agents that cause inflammation and lead to permanent fibrosis

4

Fibrosing disorders

idiopathic pulmonary fibrosis/UIP
nonspecific interstitial pneumonia
cytogenic organizing pneumonia

5

pathological pattern for IPF and other associated conditions

usual interstitial pneumonia (UIP)

6

diagnosis of exclusion

idiopathic pulmonary fibrosis (IPF)/ UIP
NSIP

7

main cause IPF

smoking

8

genetic mutations associated with IPF

TERT and TERC- telomerase
increased MUC5B secretion

9

pathological markers for UIP/IPF

honeycombing- widened septa
temporal heterogeneity
dense collagenous fibrous areas mixed with normal lung
stiff lungs

10

IPF treatment

lung transplant

11

causes of UIP

collagen vascular disease
drug toxicity
chronic hypersensitivity pneumonitis
asbestosis
familial idiopathic pulmonary fibrosis

12

radiological findings for diffuse interstitial disease

small nodules
irregular lines (ground glass shadows)

13

causes of NSIP

collagen vascular disease
hypersensitivy pneumonitis
drug induced pneumonitis
infection
immunodeficiency

14

NSIP descriptors

cellular or fibrosing pattern
lack of temporal heterogeneity
46-55

15

which is better prognosis cellular or fibrosing pattern of NSIP?

cellular

16

IPF descriptors

smoker
>50y
gradual deterioration with hypoxemia, cyanosis, clubbing

17

cytogenic organizing pneumonia

unknown cause
polypoid plugs of loose CT in alveolar ducts, alveoli, bronchioles
lack of temporal heterogeneity
no interstitial fibrosis

18

lack of temporal heterogenity

cytogenic organizing pneumonia
NSIP

19

temporal heterogenity

IPF/UIP

20

honeycomb lung

IPF/UIP
asbestosis

21

cryptogenic organizing pneumonia is similar to

**usually unknown
viral/bacterial pneumonia
inhaled toxins
collagen vascular disease
GVHD

22

diseases associated with pulmonary involvement in collagen vascular disease

systemic sclerosis
lupus
RA
prognosis better than IPF

23

pneumoconeosis

nonneoplastic responses to inhaled particulates from occupational exposures

24

pneumoconeosis diagnosis

b readings- radiography
pulmonary function tests
biopsy
autopsy

25

#1 treatment for pneumoconeoses

prevention

26

anthracosis

carbon particles along lymphatics with no fibrosis
CWP

27

simple CWP

carbon accumulation in respiratory bronchioles with fibrosis
nodules to larger macules in upper lobes and upper zones of lower lobes along the respiratory bronchioles
little to no pulmonary dysfunction

28

progressive massive fibrosis

large black scars with significant decrease in lung function
takes years to develop
center may be necrotic
severe CWP and sillicosis

29

acute silicosis

accumulation of protein rich fluid in alveoli

30

accelerated silicosis

nodular fibrosis complications in years

31

preferred lob for silicosis

upper lobes

32

which type of asbestos is worse

amphibole is worse than chrysotile
chrysotile is more common in US

33

preferred lobe for asbestosis

lower

34

pathological features of asbestosis

honeycombing
pleural plaques
asbestos bodies- fiber coated in iron