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Flashcards in SARS Deck (22):
1

SARS is what type of virus

coronavirus

2

coronavirus features

enveloped
ss + RNA
easily mutatable
peplomers on surface- club shaped
irregularly shaped
60-220nm

3

surface proteins on coronaviruses

spike glycoprotein
membrane glycprotein
hemagglutinin esterase
nucleocapsid phosphoprotein

4

spike glycoprotein

receptor binding and cell fusion

5

membrane glycoprotein

budding and envelop formation

6

hemagglutinin esterase

attachment of silic acids

7

nucleocapsid phosphoprotein

associates with viral RNA genome and cell cycle regulation

8

SARS potential drug target

3CLpro or NSP2- main protease that cleaves the polypro tin
drug blocks its action to prevent virus maturation and spread

9

coronavirus life cycle

1. attaches to host via O-acetylated silic acid host receptor
2. endocytosed
3. begins protein synthesis in cytoplasm
4. large polyprotein synthesized and cleaved into necessary proteins

10

SARS source

bats in china

11

SARS transmission

close contact with people via respiratory droplets OR contact with contaminated fomite and then touching eye, nose, mouth

12

what does SARS cause

viral pneumonia

13

symptoms of SARS

fever
dry cough
dyspnea
headache
hypoxemia

14

lab findings associated with SARS

decreased WBC
increased AFT (liver damage)

15

cause of death in SARS

respiratory failure from alveolar damage

16

disease progression in SARS

better in week 1
worse in week 2- immune response

17

SARS diagnosis

ELISA
RT-PCR

18

which is more closely related to other corona viruses

MERS

19

MERS

middle east respiratory syndrome

20

SARS

sudden acute respiratory syndrome

21

structural similarity between MERS and SARS

spike glycoprotein

22

MERS reservoir

bat