Antiprotozoan therapy Flashcards Preview

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Flashcards in Antiprotozoan therapy Deck (14):
1

Patient has toxoplasmosis, what is treatment of choice?

Pyrimethamine + sulfadiazine

2

Patient has Trypanosmoa brucei, what is treatment of choice?

suramin (blood) and melarsoprol (cns)

3

Patient has T. cruzi, what is treatment of choice?

nifurtimox or benznidazole

4

Chloroquine mech

Block detoxification of heme into hemozoin. Heme accumulates and is toxic to plasmodia

5

Chloroquine is used to treat all plasmodium species except which one? why? how?

P. falciparum; frequency of resistance too high; membrane pump that decreases intracellular concentration of drug.

6

What is the treatment of P. Falciparum?

artemether/lumefantrine OR atovaquone/proguanil.

7

Treatment for giardiasis?

Tinidazole or metronidazole

7

Treatment for giardiasis?

Tinidazol

8

Treatment for entamoeba histolytica

Metronidazole, iodoquinol for asymptomatic cyst passers

9

Treatment for cryptosporidium

Prevention by filtering city water supplies. Nitazoxanide in immunocompetent hosts

10

Treatment for naegleria fowleri

Amphotercin B

11

Leishmania donovani

Amphotericin B, sodium stibogluconate

12

Babesia

Atovaquone + azithromycin

13

Plasmodium treatment

1) Begin with chloroquine, which blocks plasmodium heme polymerase 2) if resistant use mefloquine or atovaquone/proguanil 3) if life threatening use IV quinidine (test for G6PD deficiency) 4) for P vivax/ovale: add primaquine for hypnozoite (test for G6PD deficiency)