Flashcards in FA Oncogenes Deck (15)
Gain of function leads to increased cancer risk; need damage to how many alleles needed?
CML, ALL; Tyrosine Kinase
Follicular and undifferentiate lymphomas; anti-apoptotic molecule (inhibits apoptosis)
Melanoma; Serine/threonine kinase
Gastrointestinal stromal tumor; cytokine receptor (for stem cell factor)
Burkitt lymphoma; transcription factor
Breast, Ovarian, and Gastric Carcinomas; Tyrosine Kinase
(L)ung tumor; Transcription factor
(N)euroblastoma; Transcription factor
Colon cancer, lung cancer, pancreatic cancer; GTPase
MEN 2A and 2B; Tyrosine Kinase
Which have tyrosine kinase activities?
1) ret, 2) HER2/NEU (c-erbB2) 3) BCR-ABL
What are the transcription factors?
1) c-myc 2) L-myc 3) N-myc
Which is the GTPase?