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Flashcards in FA Oncogenes Deck (15):
1

Gain of function leads to increased cancer risk; need damage to how many alleles needed?

1

2

BCR-ABL

CML, ALL; Tyrosine Kinase

3

bcl-2

Follicular and undifferentiate lymphomas; anti-apoptotic molecule (inhibits apoptosis)

4

BRAF

Melanoma; Serine/threonine kinase

5

c-kit

Gastrointestinal stromal tumor; cytokine receptor (for stem cell factor)

6

c-myc

Burkitt lymphoma; transcription factor

7

HER2/neu (c-erbB2)

Breast, Ovarian, and Gastric Carcinomas; Tyrosine Kinase

8

L-myc

(L)ung tumor; Transcription factor

9

N-myc

(N)euroblastoma; Transcription factor

10

ras

Colon cancer, lung cancer, pancreatic cancer; GTPase

11

ret

MEN 2A and 2B; Tyrosine Kinase

12

Which have tyrosine kinase activities?

1) ret, 2) HER2/NEU (c-erbB2) 3) BCR-ABL

13

What are the transcription factors?

1) c-myc 2) L-myc 3) N-myc

14

Which is the GTPase?

ras

15

which is the serine/threonine kinase?

BRAF