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Flashcards in Tumor suppressor genes Deck (6)
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1

BRCA1/2

DNA repair gene. Breast and Ovarian Cancer

2

APC/ beta catenin

Wnt signaling pathway: Colon, gastric, pancreatic cancer. Familial adenomatous polyposis.

3

TP53

Genomic instability. Most Cancers. Li-Fraumeni syndrome

4

RB

G1/S transition inhibitor: Retinoblastoma, Osteosarcoma

5

WT1

Urogenital differentiation: Wilms tumor

6

VHL

Ubiquitin ligase component: RCC, Von hippel-lindau