Opioid drugs Flashcards Preview

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Flashcards in Opioid drugs Deck (15):
1

What are the opioids?

Morphine, fentanyl, Codeine, loperamide, methadone, meperidine, dextromethorphan, diphenoxylate

2

Mech of opiods

Agonists at opiod receptors (mu = morphine, delta = enkephalin, kappa = dynorphin) to modulate synaptic transmission- open K+ channels, close Ca+ channels, decrease synaptic transmission. Inhibit release of ACh, norepinephrine, 5-HT, glutamate, substance P

3

Dextromethorphan use

cough suppression

4

loperamide and diphenoxylate use

diarrhea

5

methadone

maintenance programs for heroin addicts

6

acute pulmonary edema, pain

all?

7

Toxicities of opioid analgesics

Addiction, respiratory depression, constipation, miosis (pinpoint pupils), additive CNS depression with other drugs.

8

What is toxicity treated with?

naloxone or naltrexone

9

What does tolerance NOT develop to?

Miosis and Constipation

10

Butorphanol mech:

mu-opiod receptor partial agonist and kappa-opioid receptor agonist; produces analgesia

11

Clinical use of Butrophanol

Sever pain (migraine, labor, etc). Causes less respiratory depression than full opioid agonists.

12

Toxicities of Butorphanol

Can cause opioid withdrawal symptoms if patient is also taking full opioid agonist (competition for opioid receptors). Overdose not easily reverse with naloxone.

13

Tramadol Mech

Very weak opioid agonist; also inhibits serotinin and norepinepherine reuptake (works on multiple neurotransmitters ('tram it all' in with tramadol)

14

Clinical use of Tramadol

Chronic pain

15

Toxicity of Tramadol

Similar to opiods. Decrease Seizure threshold. Serotonin Syndrome