Flashcards in Tumor Markers Deck (11):
Metastases to bone, liver, Paget disease of bone, seminoma (placental ALP)
normally made by fetus. hepatocellular carcinoma, hepatoblastoma, yolk sac (endodermal sinus) tumor, testicular cancer, mixed germ cell tumor (co-secreted with beta hCG)
Hydatiform moles and Choriocarcinomas (gestational trophoblastic disease), testicular cancer; Commonly associated with pregnancy
Medullary thyroid carcinoma
CarcinoEmbryonicAntigen. Very nonspecific but produced by 70% of colorectal and pancreatic cancers; also produced by gastric, breast, and medullary thyroid carcinomas.
Prostate-specific antigen. Used to follow prostate adenocarcinoma. Can also be elevated in BPH and prstatitis. questionable risk/benefit for screening.
Neural crest origin (melanomas, neural tumors, scwannomas, langerhans cell histiocytosis)