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Flashcards in Tumor Markers Deck (11):
1

Alk Phos

Metastases to bone, liver, Paget disease of bone, seminoma (placental ALP)

2

alpha fetoprotein

normally made by fetus. hepatocellular carcinoma, hepatoblastoma, yolk sac (endodermal sinus) tumor, testicular cancer, mixed germ cell tumor (co-secreted with beta hCG)

3

B-hCG

Hydatiform moles and Choriocarcinomas (gestational trophoblastic disease), testicular cancer; Commonly associated with pregnancy

4

CA-15-3/CA-27-29

Breast Cancer

5

CA-19-9

Pancreatic Adenocarcinoma.

6

CA-125

Ovarian cancer

7

Calcitonin

Medullary thyroid carcinoma

8

CEA

CarcinoEmbryonicAntigen. Very nonspecific but produced by 70% of colorectal and pancreatic cancers; also produced by gastric, breast, and medullary thyroid carcinomas.

9

PSA

Prostate-specific antigen. Used to follow prostate adenocarcinoma. Can also be elevated in BPH and prstatitis. questionable risk/benefit for screening.

10

S-100

Neural crest origin (melanomas, neural tumors, scwannomas, langerhans cell histiocytosis)

11

TRAP

Tartrate-Resistant Acid Phosphatase (TRAP). Hair cell Leukemia (B cell neoplasm). TRAP the hairy animal. Largely replaced by flow cytometry