Flashcards in Tumor Markers Deck (11)
Metastases to bone, liver, Paget disease of bone, seminoma (placental ALP)
normally made by fetus. hepatocellular carcinoma, hepatoblastoma, yolk sac (endodermal sinus) tumor, testicular cancer, mixed germ cell tumor (co-secreted with beta hCG)
Hydatiform moles and Choriocarcinomas (gestational trophoblastic disease), testicular cancer; Commonly associated with pregnancy
Medullary thyroid carcinoma
CarcinoEmbryonicAntigen. Very nonspecific but produced by 70% of colorectal and pancreatic cancers; also produced by gastric, breast, and medullary thyroid carcinomas.
Prostate-specific antigen. Used to follow prostate adenocarcinoma. Can also be elevated in BPH and prstatitis. questionable risk/benefit for screening.
Neural crest origin (melanomas, neural tumors, scwannomas, langerhans cell histiocytosis)