Flashcards in drug reactions Deck (45):
1
Cardio - what drugs cause flushing?
Vancomycin, Adenosine, Niacin, Ca channel blockers
2
Cardio - coronary vasospasm
Cocaine, sumatriptan, ergot alkaloids
3
Cardio - Torsades
Class III (i.e sotalol) and class IA (i.e. quinidine), antiarrhthamics, macrolide antibiotics, antipsychotics, TCAs
4
Endocrin -hot flashes
tamoxifen, clomiphene
5
Endocrin - hyperglycemia
Tacrolimus, Protease inhibitors, Niacin, HCTZ, Beta blockers (because remember beta stimulation causes an increase in insulin), Corticosteroids.
6
Endocrin - hypothyroid
lithium, amiodarone, sulfonamides
7
Endocrin -- Acute cholestatic hepatitis, jaundice
Erythromycin
8
Endocrin - Diarrhea
Metformin, Erythromycin, Cochicine, Orlistat, Acarbose (might excite colon on accident)
9
Endocrin - focal to massive hepatic necrosis
Halothane, Amanita phalloides (death cap mushroom), Valproic acid, Acetaminophen (HAVAc on the liver)
10
Endocrin -hepatitis
Isoniazid (INH)
11
Endocrin -Pancreatitis -
Didansosine, Corticosteroids, Alcohol, Valproic acid, Azathioprine, Diuretics (furosemide, HCTZ). (Drugs Causing A Violent Abdominal Distress)
12
pseudomembranou colitis
Clindamycin, ampicillin, cephalosporins
13
hematologic - (A)granulocytosis
Dapsone, Clozapine, Carbamazepine, Colchicine, Methimazole, Propylthiouracil (Drugs CCCrush Myeloblasts and Promyelocytes)
14
hematologic - Aplastic Anemia
Carbamazepine, Methimazole, NSAIDS, Benzene, Chloramphenicol, Propylthiouracil (Can't Make New Blood Cells Properly)
15
hematologic - Direct Coombs positive hemolytic anemia
Methyldopa, penicillin
16
hematologic - gray baby
chloramphenicol
17
hematologic- Hemolysis in G6PDH
INH, Sulfonamides, Dapsone, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin. (hemolysis IS D PAIN)
18
hematologic- megaloBLASTic anemia
Phenytoin, Methotrexate, Sulfa drugs (having a BLAST with PMS
19
hematologic- Thrombocytopenia
Heparin, Cimetidine
20
hematologic- Thrombotic complications
OCPs (i.e. estrogens)
21
musc/skin/connective tissue - fat redistribution
protease inhibitors, glucocorticoids
22
musc/skin/connective tissue - gingival hyperplasia
phenytoin, verapamil, cyclosporine, nifedipine
23
musc/skin/connective tissue -hyperuricemia (gout)
Pyrazinamide, Thiazides, furosemide, niacin, cyclosporine (painful Tophi and Feet Need Care)
24
musc/skin/connective tissue -hematologic- myopathy
fibrates, niacin, colchicine, hydroxychloroquine, interferon alpha, penicillamine, statins, glucocorticoids
25
musc/skin/connective tissue - osteoporosis
corticosteroids, heparin
26
musc/skin/connective tissue -photosensitivity
sulfonamides, amiodarone, tetracyclines (5-FU)
27
musc/skin/connective tissue - Rash (STEVENS-JOHNSON syndrome)
anti-epileptic drugs (ethosuximide, carbamzazepein, lamotrigine, phentoin, phenobarbital, Allopurinol, sulfa drugs, penicillin)
28
musc/skin/connective tissue -Sle like syndrome
Sulfa drugs, Hydralazine, INH, Procainamide, Phenytoin, Etanercept (having lupus is 'SHIPPE')
29
Neuro - Cinchonism
quinidine, quinine
30
Neuro -Parkinson like syndromes
Antipsychotics, Reserpine, Metoclopramide (cogwheel rigidity of the ARM)
31
Neuro -Seizures
INH (vit b6 deficiency), Bupropion, Imipenem/cilastatin, Tramadol, Enflurane, Metoclopramide (with seizures, I BITE My tongue)
32
Neuro -Tardive dyskinesia
antispychotics, metoclopramide
33
respiratory - pulmonary fibrosis
bleomycin, amiodarone, busulfan, methotrexate (breathingair badly from medications)
34
renal/genitourinary - diabetes insipidus
Lithium, demeclocycline
35
renal/genitourinary -Fanconi syndrome
Expired tetracycline
36
renal/genitourinary -hemorrhagic cystitis
cyclophosphamide, ifosfamide (prevent by coadministering with mesna)
37
renal/genitourinary -interstitial nephritis
methicillin, NSAIDS, furosemide
38
renal/genitourinary -SIADH
Carbamazepine, cyclophosphamide, SSRIs (Can't Concentrate Serum Sodium)
39
multiorgan - disulfiram like reaction
metronidazole, cephalosporins, griseofulvin, procarbazine, 1st generation sulfonylureas
40
multiorgan - nephrotoxicity ototoxicity
Aminglcosides, vanomycin, loop diuretics, cisplatin
41
CYP inducers
chronic alcohol use, Modafinil, St. John's wort, Phenytoin, Phenobarbital, Nevirapine, Rifampin, Griseofulvin, Carbamazepine
42
CYP inhibitors
acute alcohol abuse, gemfibrozil, ciprofloxacin, Isoniazid, Grapefruti Juice, Quinidine, Amiodarone, Ketoconazole, Macrolides, Sulfonamides, Cimetidine, Ritonavir
43
Sulfa drugs
Probenecid, Furosemide, Acetazolamide, Celecoxib, Thiazides, Sulfonamide antibiotics, Sulfasalazine, Sulfonylureas.
44
What are the non-depolarizing paralytics?
Atracurium or vecuronium
45