drug reactions

Question 1

Cardio - what drugs cause flushing?

Answer 1

Vancomycin, Adenosine, Niacin, Ca channel blockers

Question 2

Cardio - coronary vasospasm

Answer 2

Cocaine, sumatriptan, ergot alkaloids

Question 3

Cardio - Torsades

Answer 3

Class III (i.e sotalol) and class IA (i.e. quinidine), antiarrhthamics, macrolide antibiotics, antipsychotics, TCAs

Question 4

Endocrin -hot flashes

Answer 4

tamoxifen, clomiphene

Question 5

Endocrin - hyperglycemia

Answer 5

Tacrolimus, Protease inhibitors, Niacin, HCTZ, Beta blockers (because remember beta stimulation causes an increase in insulin), Corticosteroids.

Question 6

Endocrin - hypothyroid

Answer 6

lithium, amiodarone, sulfonamides

Question 7

Endocrin – Acute cholestatic hepatitis, jaundice

Answer 7

Erythromycin

Question 8

Endocrin - Diarrhea

Answer 8

Metformin, Erythromycin, Cochicine, Orlistat, Acarbose (might excite colon on accident)

Question 9

Endocrin - focal to massive hepatic necrosis

Answer 9

Halothane, Amanita phalloides (death cap mushroom), Valproic acid, Acetaminophen (HAVAc on the liver)

Question 10

Endocrin -hepatitis

Answer 10

Isoniazid (INH)

Question 11

Endocrin -Pancreatitis -

Answer 11

Didansosine, Corticosteroids, Alcohol, Valproic acid, Azathioprine, Diuretics (furosemide, HCTZ). (Drugs Causing A Violent Abdominal Distress)

Question 12

pseudomembranou colitis

Answer 12

Clindamycin, ampicillin, cephalosporins

Question 13

hematologic - (A)granulocytosis

Answer 13

Dapsone, Clozapine, Carbamazepine, Colchicine, Methimazole, Propylthiouracil (Drugs CCCrush Myeloblasts and Promyelocytes)

Question 14

hematologic - Aplastic Anemia

Answer 14

Carbamazepine, Methimazole, NSAIDS, Benzene, Chloramphenicol, Propylthiouracil (Can’t Make New Blood Cells Properly)

Question 15

hematologic - Direct Coombs positive hemolytic anemia

Answer 15

Methyldopa, penicillin

Question 16

hematologic - gray baby

Answer 16

chloramphenicol

Question 17

hematologic- Hemolysis in G6PDH

Answer 17

INH, Sulfonamides, Dapsone, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin. (hemolysis IS D PAIN)

Question 18

hematologic- megaloBLASTic anemia

Answer 18

Phenytoin, Methotrexate, Sulfa drugs (having a BLAST with PMS

Question 19

hematologic- Thrombocytopenia

Answer 19

Heparin, Cimetidine

Question 20

hematologic- Thrombotic complications

Answer 20

OCPs (i.e. estrogens)

Question 21

musc/skin/connective tissue - fat redistribution

Answer 21

protease inhibitors, glucocorticoids

Question 22

musc/skin/connective tissue - gingival hyperplasia

Answer 22

phenytoin, verapamil, cyclosporine, nifedipine

Question 23

musc/skin/connective tissue -hyperuricemia (gout)

Answer 23

Pyrazinamide, Thiazides, furosemide, niacin, cyclosporine (painful Tophi and Feet Need Care)

Question 24

musc/skin/connective tissue -hematologic- myopathy

Answer 24

fibrates, niacin, colchicine, hydroxychloroquine, interferon alpha, penicillamine, statins, glucocorticoids

Question 25

musc/skin/connective tissue - osteoporosis

Answer 25

corticosteroids, heparin

Question 26

musc/skin/connective tissue -photosensitivity

Answer 26

sulfonamides, amiodarone, tetracyclines (5-FU)

Question 27

musc/skin/connective tissue - Rash (STEVENS-JOHNSON syndrome)

Answer 27

anti-epileptic drugs (ethosuximide, carbamzazepein, lamotrigine, phentoin, phenobarbital, Allopurinol, sulfa drugs, penicillin)

Question 28

musc/skin/connective tissue -Sle like syndrome

Answer 28

Sulfa drugs, Hydralazine, INH, Procainamide, Phenytoin, Etanercept (having lupus is 'SHIPPE')

Question 29

Neuro - Cinchonism

Answer 29

quinidine, quinine

Question 30

Neuro -Parkinson like syndromes

Answer 30

Antipsychotics, Reserpine, Metoclopramide (cogwheel rigidity of the ARM)

Question 31

Neuro -Seizures

Answer 31

INH (vit b6 deficiency), Bupropion, Imipenem/cilastatin, Tramadol, Enflurane, Metoclopramide (with seizures, I BITE My tongue)

Question 32

Neuro -Tardive dyskinesia

Answer 32

antispychotics, metoclopramide

Question 33

respiratory - pulmonary fibrosis

Answer 33

bleomycin, amiodarone, busulfan, methotrexate (breathingair badly from medications)

Question 34

renal/genitourinary - diabetes insipidus

Answer 34

Lithium, demeclocycline

Question 35

renal/genitourinary -Fanconi syndrome

Answer 35

Expired tetracycline

Question 36

renal/genitourinary -hemorrhagic cystitis

Answer 36

cyclophosphamide, ifosfamide (prevent by coadministering with mesna)

Question 37

renal/genitourinary -interstitial nephritis

Answer 37

methicillin, NSAIDS, furosemide

Question 38

renal/genitourinary -SIADH

Answer 38

Carbamazepine, cyclophosphamide, SSRIs (Can't Concentrate Serum Sodium)

Question 39

multiorgan - disulfiram like reaction

Answer 39

metronidazole, cephalosporins, griseofulvin, procarbazine, 1st generation sulfonylureas

Question 40

multiorgan - nephrotoxicity ototoxicity

Answer 40

Aminglcosides, vanomycin, loop diuretics, cisplatin

Question 41

CYP inducers

Answer 41

chronic alcohol use, Modafinil, St. John's wort, Phenytoin, Phenobarbital, Nevirapine, Rifampin, Griseofulvin, Carbamazepine

Question 42

CYP inhibitors

Answer 42

acute alcohol abuse, gemfibrozil, ciprofloxacin, Isoniazid, Grapefruti Juice, Quinidine, Amiodarone, Ketoconazole, Macrolides, Sulfonamides, Cimetidine, Ritonavir

Question 43

Sulfa drugs

Answer 43

Probenecid, Furosemide, Acetazolamide, Celecoxib, Thiazides, Sulfonamide antibiotics, Sulfasalazine, Sulfonylureas.

Question 44

What are the non-depolarizing paralytics?

Answer 44

Atracurium or vecuronium

Question 45

'prost'

Answer 45

Latanoprost