Ovarian Neoplasms Flashcards Preview

First Aid > Ovarian Neoplasms > Flashcards

Flashcards in Ovarian Neoplasms Deck (18):
1

How does an ovarian neoplasm present?

adnexal mass, abdominal distension, bowel obstruction, pleural effusion. DX: surgically. Monitor progression by measuring CA-125 levels.

2

What are the Benign ovarian neoplasms?

Serous cystadenoma, mucinous cystadenoma, endometrioma, mature cystic teratoma (dermoid cyst), Brenner tumor, Fibromas, Thecoma

3

Serous cystadenoma

Most common ovarian neoplasm. Thin walled, uni or multilocular. Lined with fallopian-like epithelium. Often bilateral

4

Mucinous cystadenoma

Multiloculated, large. Lined by mucus secreting epithelium.

5

Endometrioma

Mass arising from growth of ectopic endometrial tissue. Complex mass on ultrasound. Presents with pelvic pain, dysmenorrhea, dysparenuia

6

Mature Cystic Teratoma (dermoid cyst)

Germ cell tumor, most common ovarian tumor in women (20-30 years old). Can contain elements from all 3 germ layers; teeth, hair, sebum are common components. Can present with pain secondary to ovarian enlargement or torsion. Can also contain functional thyroid tissue and present as hyperthyroidism (struma ovarii)

7

Brenner tumor

looks like bladder. solid tumor that is pale yellow-tan in color and apears encapsulated. "coffee bean" nuclei on H&E

8

Fibromas

Bundles of spindle shaped fibroblasts. Meigs syndome - triad of ovarian fibroma, ascites, and hydrothorax. Pulling sensation in groin

9

Thecoma

Like granulosa cell tumors, may produce estrogen. Usually present as abnormal uterine bleeding in a postmenopausal woman.

10

What are the malignant ovarian neoplasms?

Immature teratoma, granulosa cell tumor, serous cystadenocarcinoma, mucinous cystadenocarcinoma, dysgerminoma, choriocarcinoma, yolk sac (endodermal sinus) tumor, krukenberg tumor

11

Immature Teratoma

Aggressive, contains fetal tissue, neuroectoderm. Immature teratoma is most typically represented by immature/embryonic like neural tissue. Mature teratoma are more likely to contain thyroid tissue.

12

Granulosa cell tumor

Most common sex cord stromal tumor. Predomionanty women in their 50s. Often produce estrogen and/or progesterone and present with abnormal uterine bleeding, sexual precocity (in pre-adolescents), breast tenderness. Histology shows Call-Exner Bodies (resemble primordial follicles).

13

Serous Cystadenocarcinoma

Most common ovarian neoplasm, frequently bilateral. Psammoma bodeis

14

Mucinous Cystadenocarcinoma

Pseudomyxoma Peritonei-intraperitoneal accumulation of mucinous material from ovarian or appendiceal tumor.

15

Dysgerminoma

Most common in adolescents. Equivalent to male seminoma but more rare. 1% of all ovarian tumors; 30% of germ cell tumors. Sheets of uniform 'fried egg' cells. hCG, LDH = tumor markers.

16

Choriocarcinoma

Rare; can develop during or after pregnancy in mother or baby. malignancy of trophoblastic tissue (cytotrophoblasts, syncytiotrophoblasts); NO chorionic villi present. Increase frequency of theca-lutein cysts. Presents with abnormal B-hCG, shortness of breath, hemoptysis. Hematogenous spread to lungs. Very responsive to chemotherapy.

17

Yolk Sac (endodermal Sinus) tumor

Aggressive, in ovaries or testes (boys) and sacrococcygeal area in young children. Most common tumor in male infants. Yellow, friable (hemorrhagic), solid mass. 50% have Schiller-Duval bodies (resemble glomeruli). AFP tumor marker

18

Krukenberg tumor

GI malignancy that metastasizes to the ovaries, causing a mucin-secreting signet cell adenocardinoma.