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Flashcards in Protooncogenes Deck (7)
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1

What are the Proto-oncogenes (1 hit gain of function)

RAS, MYC, ERBB1 (EGFR), ERBB2 (HER2), ABL, BRAF

2

RAS

GTP-binding protein: Cholangiocarcinoma, Pancreatic adenocarcinoma

3

MYC

Transcription Factor: Burkitt Lymphoma

4

ERBB1 (EGFR)

Receptor Tyrosine Kinase. Lung Adenocarcinoma.

5

ERBB2 (HER2)

Receptor tyrosine kinase. Breast Cancer

6

ABL

Nonreceptor tyrosine kinase. Chronic myelogenous leukemia

7

BRAF

Ras signal transduction. Hairy cell leukemia, Melanoma