Antipsychotics Flashcards Preview

Pharmacology > Antipsychotics > Flashcards

Flashcards in Antipsychotics Deck (31):
1

First generation antipsychotics

Haloperidol, Fluphenazine, perphenazine, Thioridazine, Chlorpromazine

2

First Gen MOA

D2 receptor antagonist

3

First gen ADR

weight gain, sedation, increased prolaction, increased EPS, anticholinergic

4

Second generation antipsychotics

Aripiprazole, Brexipiprazole, Asenapine, Clozapine, Iloperidone, Lurasidone, Olanzapine, Paliperidone, Quetiapine, Risperidone, Ziprasidone

5

2nd gen MOA

D2 receptor antagonist, 5HT1, 5HT2A

6

2nd gen ADR

weight gain, sedation, anticholinergic effects, Hypotension, diabetes, seizures

7

Antipsychotic black box warning

increased mortality in elderly patients with dementia related psychosis

8

Clozapine ADR

increased risk of agranulocytosis, myocarditis, orthostasis, bradycardia, lower seizure threshold

9

Monitoring SGA

PMH, FMH, CVH, BMI, Waist circumference, BO, fasting glucose, fasting lipid

10

Iloperidone

schizophrenia in adults

11

Iloperidone MOA

DA and 5-HT2 antagonist, alpha adrenergic antagonism

12

Iloperidone ADR

dizziness, somnolence, tachy, nause, dry mouth, impaired thinking, long QT, NMS, tardive, dyskinesia, orthostasis, hyperprolactinemia, priapism

13

Paliperidone

schizophrenia, schizoaffective disorder

14

Paliperidone MOA

DA, 5-HT2a, Hi, alpha receptor antagonist

15

Paliperidone ADR

HA, tachy, somnolence, anxiety, akathisia, EPS

16

Asenapine

manic or mixed bipolar episodes, acute or maintenance of schizophrenia

17

Asenapine MOA

DA, 5-HT, NE, H1

18

Asenapine ADR

insomnia, somnolence, NV, anxiety, agitation, HA, constipation, psychosis,

19

Brexipiprazole

schizophrenia, adjunct for MDD

20

Brexipiprazole warnings

increased mortality and CVA in elderly dementia patiens

21

Brexipiprazole ADR

hyperglycemia, hyperlipidemia, weight gain, blood dyscrasias, akathasia, somnolence, anxiety, restlessness

22

Acute dystonia

Benzotropine mesylate, diphenhydramine, trihexphenadryl

23

Akathisia

Clonazepam, lorazepam, pramipexole, propranolol, ropinerole

24

Neuroepiletic syndrome

dantrolene sodium, anticholinergics, dopamine agonists,

25

Parkinsonism

amantadine, anitcholinergics, pramipexole, ropinerole

26

Neuroepileptic induced catatonia

anitcholinergics, bromocriptine, dopamine agonists

27

Lithium

first line for manic episodes of bipolar disorder, first line for maintenance of bipolar disorder

28

Lithium contraindications

CV disease, renal disease, dehydration, sodium depletion, diuretics,

29

Lithium warnings

pregancy, renal toxicity

30

Lithium toxicity

>1.4 meq/L. diarrhea, nausea, vomiting, drowsiness, muscle weakness, lack of coordination. at higher levels, giddiness, ataxia, blurred vision, tinnitus, dilute urine

31

Lithium ADR

Neuro, CV, GI (anorexia, NVD), GU (albuminuria, oliguria, polyuria) Derm (drying and thinning of hair, alopecia, folliculitis), ANS (blurred vision, dry mouth)