Antipsychotics Flashcards Preview

Question 1

1

First generation antipsychotics

Answer

Haloperidol, Fluphenazine, perphenazine, Thioridazine, Chlorpromazine

Question 2

2

First Gen MOA

Answer

D2 receptor antagonist

Question 3

3

First gen ADR

Answer

weight gain, sedation, increased prolaction, increased EPS, anticholinergic

Question 4

4

Second generation antipsychotics

Answer

Aripiprazole, Brexipiprazole, Asenapine, Clozapine, Iloperidone, Lurasidone, Olanzapine, Paliperidone, Quetiapine, Risperidone, Ziprasidone

Question 5

5

2nd gen MOA

Answer

D2 receptor antagonist, 5HT1, 5HT2A

Question 6

6

2nd gen ADR

Answer

weight gain, sedation, anticholinergic effects, Hypotension, diabetes, seizures

Question 7

7

Antipsychotic black box warning

Answer

increased mortality in elderly patients with dementia related psychosis

Question 8

8

Clozapine ADR

Answer

increased risk of agranulocytosis, myocarditis, orthostasis, bradycardia, lower seizure threshold

Question 9

9

Monitoring SGA

Answer

PMH, FMH, CVH, BMI, Waist circumference, BO, fasting glucose, fasting lipid

Question 10

10

Iloperidone

Answer

schizophrenia in adults

Question 11

11

Iloperidone MOA

Answer

DA and 5-HT2 antagonist, alpha adrenergic antagonism

Question 12

12

Iloperidone ADR

Answer

dizziness, somnolence, tachy, nause, dry mouth, impaired thinking, long QT, NMS, tardive, dyskinesia, orthostasis, hyperprolactinemia, priapism

Question 13

13

Paliperidone

Answer

schizophrenia, schizoaffective disorder

Question 14

14

Paliperidone MOA

Answer

DA, 5-HT2a, Hi, alpha receptor antagonist

Question 15

15

Paliperidone ADR

Answer

HA, tachy, somnolence, anxiety, akathisia, EPS

Question 16

16

Asenapine

Answer

manic or mixed bipolar episodes, acute or maintenance of schizophrenia

Question 17

17

Asenapine MOA

Answer

DA, 5-HT, NE, H1

Question 18

18

Asenapine ADR

Answer

insomnia, somnolence, NV, anxiety, agitation, HA, constipation, psychosis,

Question 19

19

Brexipiprazole

Answer

schizophrenia, adjunct for MDD

Question 20

20

Brexipiprazole warnings

Answer

increased mortality and CVA in elderly dementia patiens

Question 21

21

Brexipiprazole ADR

Answer

hyperglycemia, hyperlipidemia, weight gain, blood dyscrasias, akathasia, somnolence, anxiety, restlessness

Question 22

22

Acute dystonia

Answer

Benzotropine mesylate, diphenhydramine, trihexphenadryl

Question 23

23

Akathisia

Answer

Clonazepam, lorazepam, pramipexole, propranolol, ropinerole

Question 24

24

Neuroepiletic syndrome

Answer

dantrolene sodium, anticholinergics, dopamine agonists,

Question 25

25

Parkinsonism

Answer

amantadine, anitcholinergics, pramipexole, ropinerole

Question 26

26

Neuroepileptic induced catatonia

Answer

anitcholinergics, bromocriptine, dopamine agonists

Question 27

27

Lithium

Answer

first line for manic episodes of bipolar disorder, first line for maintenance of bipolar disorder

Question 28

28

Lithium contraindications

Answer

CV disease, renal disease, dehydration, sodium depletion, diuretics,

Question 29

29

Lithium warnings

Answer

pregancy, renal toxicity

Question 30

30

Lithium toxicity

Answer

>1.4 meq/L. diarrhea, nausea, vomiting, drowsiness, muscle weakness, lack of coordination. at higher levels, giddiness, ataxia, blurred vision, tinnitus, dilute urine

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