Antipsychotics

Question 1

First generation antipsychotics

Answer 1

Haloperidol, Fluphenazine, perphenazine, Thioridazine, Chlorpromazine

Question 2

First Gen MOA

Answer 2

D2 receptor antagonist

Question 3

First gen ADR

Answer 3

weight gain, sedation, increased prolaction, increased EPS, anticholinergic

Question 4

Second generation antipsychotics

Answer 4

Aripiprazole, Brexipiprazole, Asenapine, Clozapine, Iloperidone, Lurasidone, Olanzapine, Paliperidone, Quetiapine, Risperidone, Ziprasidone

Question 5

2nd gen MOA

Answer 5

D2 receptor antagonist, 5HT1, 5HT2A

Question 6

2nd gen ADR

Answer 6

weight gain, sedation, anticholinergic effects, Hypotension, diabetes, seizures

Question 7

Antipsychotic black box warning

Answer 7

increased mortality in elderly patients with dementia related psychosis

Question 8

Clozapine ADR

Answer 8

increased risk of agranulocytosis, myocarditis, orthostasis, bradycardia, lower seizure threshold

Question 9

Monitoring SGA

Answer 9

PMH, FMH, CVH, BMI, Waist circumference, BO, fasting glucose, fasting lipid

Question 10

Iloperidone

Answer 10

schizophrenia in adults

Question 11

Iloperidone MOA

Answer 11

DA and 5-HT2 antagonist, alpha adrenergic antagonism

Question 12

Iloperidone ADR

Answer 12

dizziness, somnolence, tachy, nause, dry mouth, impaired thinking, long QT, NMS, tardive, dyskinesia, orthostasis, hyperprolactinemia, priapism

Question 13

Paliperidone

Answer 13

schizophrenia, schizoaffective disorder

Question 14

Paliperidone MOA

Answer 14

DA, 5-HT2a, Hi, alpha receptor antagonist

Question 15

Paliperidone ADR

Answer 15

HA, tachy, somnolence, anxiety, akathisia, EPS

Question 16

Asenapine

Answer 16

manic or mixed bipolar episodes, acute or maintenance of schizophrenia

Question 17

Asenapine MOA

Answer 17

DA, 5-HT, NE, H1

Question 18

Asenapine ADR

Answer 18

insomnia, somnolence, NV, anxiety, agitation, HA, constipation, psychosis,

Question 19

Brexipiprazole

Answer 19

schizophrenia, adjunct for MDD

Question 20

Brexipiprazole warnings

Answer 20

increased mortality and CVA in elderly dementia patiens

Question 21

Brexipiprazole ADR

Answer 21

hyperglycemia, hyperlipidemia, weight gain, blood dyscrasias, akathasia, somnolence, anxiety, restlessness

Question 22

Acute dystonia

Answer 22

Benzotropine mesylate, diphenhydramine, trihexphenadryl

Question 23

Akathisia

Answer 23

Clonazepam, lorazepam, pramipexole, propranolol, ropinerole

Question 24

Neuroepiletic syndrome

Answer 24

dantrolene sodium, anticholinergics, dopamine agonists,

Question 25

Parkinsonism

Answer 25

amantadine, anitcholinergics, pramipexole, ropinerole

Question 26

Neuroepileptic induced catatonia

Answer 26

anitcholinergics, bromocriptine, dopamine agonists

Question 27

Lithium

Answer 27

first line for manic episodes of bipolar disorder, first line for maintenance of bipolar disorder

Question 28

Lithium contraindications

Answer 28

CV disease, renal disease, dehydration, sodium depletion, diuretics,

Question 29

Lithium warnings

Answer 29

pregancy, renal toxicity

Question 30

Lithium toxicity

Answer 30

>1.4 meq/L. diarrhea, nausea, vomiting, drowsiness, muscle weakness, lack of coordination. at higher levels, giddiness, ataxia, blurred vision, tinnitus, dilute urine

Question 31

Lithium ADR

Answer 31

Neuro, CV, GI (anorexia, NVD), GU (albuminuria, oliguria, polyuria) Derm (drying and thinning of hair, alopecia, folliculitis), ANS (blurred vision, dry mouth)