Flashcards in Antipsychotics Deck (31):
1
First generation antipsychotics
Haloperidol, Fluphenazine, perphenazine, Thioridazine, Chlorpromazine
2
First Gen MOA
D2 receptor antagonist
3
First gen ADR
weight gain, sedation, increased prolaction, increased EPS, anticholinergic
4
Second generation antipsychotics
Aripiprazole, Brexipiprazole, Asenapine, Clozapine, Iloperidone, Lurasidone, Olanzapine, Paliperidone, Quetiapine, Risperidone, Ziprasidone
5
2nd gen MOA
D2 receptor antagonist, 5HT1, 5HT2A
6
2nd gen ADR
weight gain, sedation, anticholinergic effects, Hypotension, diabetes, seizures
7
Antipsychotic black box warning
increased mortality in elderly patients with dementia related psychosis
8
Clozapine ADR
increased risk of agranulocytosis, myocarditis, orthostasis, bradycardia, lower seizure threshold
9
Monitoring SGA
PMH, FMH, CVH, BMI, Waist circumference, BO, fasting glucose, fasting lipid
10
Iloperidone
schizophrenia in adults
11
Iloperidone MOA
DA and 5-HT2 antagonist, alpha adrenergic antagonism
12
Iloperidone ADR
dizziness, somnolence, tachy, nause, dry mouth, impaired thinking, long QT, NMS, tardive, dyskinesia, orthostasis, hyperprolactinemia, priapism
13
Paliperidone
schizophrenia, schizoaffective disorder
14
Paliperidone MOA
DA, 5-HT2a, Hi, alpha receptor antagonist
15
Paliperidone ADR
HA, tachy, somnolence, anxiety, akathisia, EPS
16
Asenapine
manic or mixed bipolar episodes, acute or maintenance of schizophrenia
17
Asenapine MOA
DA, 5-HT, NE, H1
18
Asenapine ADR
insomnia, somnolence, NV, anxiety, agitation, HA, constipation, psychosis,
19
Brexipiprazole
schizophrenia, adjunct for MDD
20
Brexipiprazole warnings
increased mortality and CVA in elderly dementia patiens
21
Brexipiprazole ADR
hyperglycemia, hyperlipidemia, weight gain, blood dyscrasias, akathasia, somnolence, anxiety, restlessness
22
Acute dystonia
Benzotropine mesylate, diphenhydramine, trihexphenadryl
23
Akathisia
Clonazepam, lorazepam, pramipexole, propranolol, ropinerole
24
Neuroepiletic syndrome
dantrolene sodium, anticholinergics, dopamine agonists,
25
Parkinsonism
amantadine, anitcholinergics, pramipexole, ropinerole
26
Neuroepileptic induced catatonia
anitcholinergics, bromocriptine, dopamine agonists
27
Lithium
first line for manic episodes of bipolar disorder, first line for maintenance of bipolar disorder
28
Lithium contraindications
CV disease, renal disease, dehydration, sodium depletion, diuretics,
29
Lithium warnings
pregancy, renal toxicity
30
Lithium toxicity
>1.4 meq/L. diarrhea, nausea, vomiting, drowsiness, muscle weakness, lack of coordination. at higher levels, giddiness, ataxia, blurred vision, tinnitus, dilute urine
31