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Flashcards in Anti depressants Deck (63)
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1

Depression Symptom pneumonic

SIGECAPS- sleep, interest, guilt, energy, concentration, appetite, psychomotor, suicidal

2

Serotonin Syndrome

mental status changes, autonomic instablity, neuromuscular aberrations, GI symptoms, ocular clonus, mydriasis

3

SSRI MOA

blocks presynaptic serotonin transporter, leaves serotonin available for use

4

SSRI ADR

NV, insomnia, weight gain, HA, Bruxism, Erectile dysfunction, diaphoresis, Orthostatis, Akathasia, Osteopenia, GI Bleed, some anticholinergic

5

SSRI and pregnancy

some cardiac defects in 1st trimester, low birth weight, permaturity, neonatal withdrawal, pulmonary hypertension in 3rd trimester

6

SSRIs

Fluvoxamine, Fluoxetine, Paroxetine, Citalopram, Escitalopram, Sertraline, Vortioxetine

7

Fluoxetine

MDD, OCD, PD, bulimia

8

Fluoxetine drug interactions

CYP2d6 inhibitor

9

Paroxetine

MDD, OCD, SAD, GAD

10

Paroxetine peals

most sedating, most weight gain, sexual dysfunction, anticholinergic AE

11

Sertraline

MDD, OCD, PD, PTSD, PMDD, SAD

12

Sertraline pearls

fewer drug interactions, good for CV disease

13

Sertraline ADR

dry mouth, sedation, insomnia, tremor, dizziness, sexual dysfunction

14

Escitalopram

MDD, GAD

15

Escitalopram ADR

N, sedation, insomnia, sexual side effects

16

Citalopram pearls

lowest sexual side effects

17

SNRIs MOA

serontonin neuroepi repuptake inhibitors. Bind 5-HT and NE transporter

18

SNRI indications

depression, anxiety disorder, neuropathic pain, chronic pain, fibromyalgia

19

SNRI ADR

HTN, hyperlipidemia, dry mouth, HA, sexual dysfunction, insomnia, NV, akathasia, diaphoresis, weight changes

20

SNRI drug interactions

other serotonin drugs, MAOIS, platelet inhibitors, strong 3A4 inhibitors, 2D6 inhibitors

21

SNRIs

Venlafaxine, Desvenlafaxine, duloxetine, Milnacipran, levomilnacipran.

22

Mirtazipine

major depressive disorder

23

Mirtazipine MOA

increases central NE and 5-HT activity. 5-HT antagonist,

24

Mirtazipine ADR

sedation, somnolence, dizziness, orthostasis, weight gain, elevated cholesterol and LFT, agranulocytosis

25

Bupropion

MDD, smoking cessation

26

Bupropion MOA

weak NE and DA reuptake inhibitor

27

Bupropion ADR

agitation, anxiety, weight loss, insomnia, psychosis, hallucinations, HTN, NV, HA, dry mouth

28

Bupropion contraindications

Seizure disorders

29

Tricyclic antidepressants MOA

SNRI, anitcholinergic, alpha-adrenergic, membrane stabilizing on myocardium

30

TCA indications

depression, anxiety, bipolar disorder, OCD, neuropathic pain, migraine prophylaxis