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Flashcards in Anti depressants Deck (63):
1

Depression Symptom pneumonic

SIGECAPS- sleep, interest, guilt, energy, concentration, appetite, psychomotor, suicidal

2

Serotonin Syndrome

mental status changes, autonomic instablity, neuromuscular aberrations, GI symptoms, ocular clonus, mydriasis

3

SSRI MOA

blocks presynaptic serotonin transporter, leaves serotonin available for use

4

SSRI ADR

NV, insomnia, weight gain, HA, Bruxism, Erectile dysfunction, diaphoresis, Orthostatis, Akathasia, Osteopenia, GI Bleed, some anticholinergic

5

SSRI and pregnancy

some cardiac defects in 1st trimester, low birth weight, permaturity, neonatal withdrawal, pulmonary hypertension in 3rd trimester

6

SSRIs

Fluvoxamine, Fluoxetine, Paroxetine, Citalopram, Escitalopram, Sertraline, Vortioxetine

7

Fluoxetine

MDD, OCD, PD, bulimia

8

Fluoxetine drug interactions

CYP2d6 inhibitor

9

Paroxetine

MDD, OCD, SAD, GAD

10

Paroxetine peals

most sedating, most weight gain, sexual dysfunction, anticholinergic AE

11

Sertraline

MDD, OCD, PD, PTSD, PMDD, SAD

12

Sertraline pearls

fewer drug interactions, good for CV disease

13

Sertraline ADR

dry mouth, sedation, insomnia, tremor, dizziness, sexual dysfunction

14

Escitalopram

MDD, GAD

15

Escitalopram ADR

N, sedation, insomnia, sexual side effects

16

Citalopram pearls

lowest sexual side effects

17

SNRIs MOA

serontonin neuroepi repuptake inhibitors. Bind 5-HT and NE transporter

18

SNRI indications

depression, anxiety disorder, neuropathic pain, chronic pain, fibromyalgia

19

SNRI ADR

HTN, hyperlipidemia, dry mouth, HA, sexual dysfunction, insomnia, NV, akathasia, diaphoresis, weight changes

20

SNRI drug interactions

other serotonin drugs, MAOIS, platelet inhibitors, strong 3A4 inhibitors, 2D6 inhibitors

21

SNRIs

Venlafaxine, Desvenlafaxine, duloxetine, Milnacipran, levomilnacipran.

22

Mirtazipine

major depressive disorder

23

Mirtazipine MOA

increases central NE and 5-HT activity. 5-HT antagonist,

24

Mirtazipine ADR

sedation, somnolence, dizziness, orthostasis, weight gain, elevated cholesterol and LFT, agranulocytosis

25

Bupropion

MDD, smoking cessation

26

Bupropion MOA

weak NE and DA reuptake inhibitor

27

Bupropion ADR

agitation, anxiety, weight loss, insomnia, psychosis, hallucinations, HTN, NV, HA, dry mouth

28

Bupropion contraindications

Seizure disorders

29

Tricyclic antidepressants MOA

SNRI, anitcholinergic, alpha-adrenergic, membrane stabilizing on myocardium

30

TCA indications

depression, anxiety, bipolar disorder, OCD, neuropathic pain, migraine prophylaxis

31

TCA drug interactions

CYP 2D6 substrate, MAOI, anitcholinergics, sympathomimetics, cimetidine

32

TCA ADR

anitcholinergic, arrhythmia, sexual dysfunction, fall risk, diaphoresis

33

Trazodone

depression

34

Trazdone MOA

5-HT receptor antogonist and reuptake inhibitor

35

Trazedone ADR

sedation, somnolence, HA, dizziness, dry mouth, orthostasis, long QT, arrythmia, priapism

36

Vilazodone MOA

5-HT receptor antagonist and reuptake inhibitor

37

Vilazodone ADR

sedation, somnolence, HA, dizziness, dry mouth, orthostasis, long QT, arrhythmia, priapism

38

MAOI indications

last line for depression

39

MAOI MOA

increase levels of 5-HT, NE, DA. nonselective monoamine oxidase inhibitor

40

MAOI contraindications

HTN, CV disease, other MAOI, sympathomimetics, CNS depressants, anti HTN, buproprion, cheese, or other foods with high tyramine

41

MAOI ADR

serotonin syndrome, sexual dysfunction, myoclonus, orthostasis, HTN crisis, dizziness, drowsiness, constipation, dry mouth, weight gain

42

St Johns wort MOA

modulates 5-HT. NE, DA

43

ST johns wort interactions

potent P450 inducer. 3A4, 2C19, 1A2. increases OCP estrogen, reduces digoxin, imatinib, irinotecan levels

44

St. Johns wort ADR

insomnia, vivid dreams, restlessness, anxiety, agitation, diarrhea, dry mouth, dizziness, HA, rash, hypoglycemia, parasthesias

45

APA 2010 guidelines

SSRI, SNRI, bupropion, mirtazapine

46

APA 2016 guidelines

Cognitive behavioral therapy or Second generation SSRI

47

Drugs that cause anxiety

bupropion, clonidine, nictotine, albuterol, prednisone, amphetamines, caffeine, pesudoephedrine, levothyroxine

48

Benzodiazepines MOA

binds gamma subunit of GABA-A receptor in addition to GABA-->facilitates inhibitory effect of GABA

49

Benzodiazepine ADR

lipophilicity, sedation, confusion, disorentation, euphoria, excitement, irritability, respiratory depression, Hypotension

50

Benzodiazepine withdrawal symptoms

insomnia, restlessness, muscle tension, irritability

51

BDZ alerts

elderly patients-increased fat, increased risk of AE and increased risk of fall, pregnancy and lactation cat D

52

Buspirone MOA

partial agonist at 5HT-1A receptors

53

Buspirone

anxiety

54

Buspirone advantages

lack of dependency, less sedation, minimal DDI

55

Buspirone disadvantages

slow onset, dosed BID-TID, not effective for depression

56

Buspirone ADR

dizziness, nausea, headache

57

first line GAD

SSRI, SNRI, pregabalin

58

second line GAD

buspirone

59

last line

BDZ

60

OCD first line

SSRI

61

SAD first line

SSRI, venlafaxine

62

PTSD first line

fluoxetine, sertraline

63

PTSD second

venlafaxine