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Pharmacology > Anti depressants > Flashcards

Anti depressants Flashcards

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1
Q

Depression Symptom pneumonic

A

SIGECAPS- sleep, interest, guilt, energy, concentration, appetite, psychomotor, suicidal

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2
Q

Serotonin Syndrome

A

mental status changes, autonomic instablity, neuromuscular aberrations, GI symptoms, ocular clonus, mydriasis

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3
Q

SSRI MOA

A

blocks presynaptic serotonin transporter, leaves serotonin available for use

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4
Q

SSRI ADR

A

NV, insomnia, weight gain, HA, Bruxism, Erectile dysfunction, diaphoresis, Orthostatis, Akathasia, Osteopenia, GI Bleed, some anticholinergic

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5
Q

SSRI and pregnancy

A

some cardiac defects in 1st trimester, low birth weight, permaturity, neonatal withdrawal, pulmonary hypertension in 3rd trimester

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6
Q

SSRIs

A

Fluvoxamine, Fluoxetine, Paroxetine, Citalopram, Escitalopram, Sertraline, Vortioxetine

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7
Q

Fluoxetine

A

MDD, OCD, PD, bulimia

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8
Q

Fluoxetine drug interactions

A

CYP2d6 inhibitor

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9
Q

Paroxetine

A

MDD, OCD, SAD, GAD

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10
Q

Paroxetine peals

A

most sedating, most weight gain, sexual dysfunction, anticholinergic AE

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11
Q

Sertraline

A

MDD, OCD, PD, PTSD, PMDD, SAD

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12
Q

Sertraline pearls

A

fewer drug interactions, good for CV disease

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13
Q

Sertraline ADR

A

dry mouth, sedation, insomnia, tremor, dizziness, sexual dysfunction

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14
Q

Escitalopram

A

MDD, GAD

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15
Q

Escitalopram ADR

A

N, sedation, insomnia, sexual side effects

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16
Q

Citalopram pearls

A

lowest sexual side effects

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17
Q

SNRIs MOA

A

serontonin neuroepi repuptake inhibitors. Bind 5-HT and NE transporter

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18
Q

SNRI indications

A

depression, anxiety disorder, neuropathic pain, chronic pain, fibromyalgia

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19
Q

SNRI ADR

A

HTN, hyperlipidemia, dry mouth, HA, sexual dysfunction, insomnia, NV, akathasia, diaphoresis, weight changes

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20
Q

SNRI drug interactions

A

other serotonin drugs, MAOIS, platelet inhibitors, strong 3A4 inhibitors, 2D6 inhibitors

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21
Q

SNRIs

A

Venlafaxine, Desvenlafaxine, duloxetine, Milnacipran, levomilnacipran.

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22
Q

Mirtazipine

A

major depressive disorder

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23
Q

Mirtazipine MOA

A

increases central NE and 5-HT activity. 5-HT antagonist,

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24
Q

Mirtazipine ADR

A

sedation, somnolence, dizziness, orthostasis, weight gain, elevated cholesterol and LFT, agranulocytosis

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25
Bupropion
MDD, smoking cessation
26
Bupropion MOA
weak NE and DA reuptake inhibitor
27
Bupropion ADR
agitation, anxiety, weight loss, insomnia, psychosis, hallucinations, HTN, NV, HA, dry mouth
28
Bupropion contraindications
Seizure disorders
29
Tricyclic antidepressants MOA
SNRI, anitcholinergic, alpha-adrenergic, membrane stabilizing on myocardium
30
TCA indications
depression, anxiety, bipolar disorder, OCD, neuropathic pain, migraine prophylaxis
31
TCA drug interactions
CYP 2D6 substrate, MAOI, anitcholinergics, sympathomimetics, cimetidine
32
TCA ADR
anitcholinergic, arrhythmia, sexual dysfunction, fall risk, diaphoresis
33
Trazodone
depression
34
Trazdone MOA
5-HT receptor antogonist and reuptake inhibitor
35
Trazedone ADR
sedation, somnolence, HA, dizziness, dry mouth, orthostasis, long QT, arrythmia, priapism
36
Vilazodone MOA
5-HT receptor antagonist and reuptake inhibitor
37
Vilazodone ADR
sedation, somnolence, HA, dizziness, dry mouth, orthostasis, long QT, arrhythmia, priapism
38
MAOI indications
last line for depression
39
MAOI MOA
increase levels of 5-HT, NE, DA. nonselective monoamine oxidase inhibitor
40
MAOI contraindications
HTN, CV disease, other MAOI, sympathomimetics, CNS depressants, anti HTN, buproprion, cheese, or other foods with high tyramine
41
MAOI ADR
serotonin syndrome, sexual dysfunction, myoclonus, orthostasis, HTN crisis, dizziness, drowsiness, constipation, dry mouth, weight gain
42
St Johns wort MOA
modulates 5-HT. NE, DA
43
ST johns wort interactions
potent P450 inducer. 3A4, 2C19, 1A2. increases OCP estrogen, reduces digoxin, imatinib, irinotecan levels
44
St. Johns wort ADR
insomnia, vivid dreams, restlessness, anxiety, agitation, diarrhea, dry mouth, dizziness, HA, rash, hypoglycemia, parasthesias
45
APA 2010 guidelines
SSRI, SNRI, bupropion, mirtazapine
46
APA 2016 guidelines
Cognitive behavioral therapy or Second generation SSRI
47
Drugs that cause anxiety
bupropion, clonidine, nictotine, albuterol, prednisone, amphetamines, caffeine, pesudoephedrine, levothyroxine
48
Benzodiazepines MOA
binds gamma subunit of GABA-A receptor in addition to GABA-->facilitates inhibitory effect of GABA
49
Benzodiazepine ADR
lipophilicity, sedation, confusion, disorentation, euphoria, excitement, irritability, respiratory depression, Hypotension
50
Benzodiazepine withdrawal symptoms
insomnia, restlessness, muscle tension, irritability
51
BDZ alerts
elderly patients-increased fat, increased risk of AE and increased risk of fall, pregnancy and lactation cat D
52
Buspirone MOA
partial agonist at 5HT-1A receptors
53
Buspirone
anxiety
54
Buspirone advantages
lack of dependency, less sedation, minimal DDI
55
Buspirone disadvantages
slow onset, dosed BID-TID, not effective for depression
56
Buspirone ADR
dizziness, nausea, headache
57
first line GAD
SSRI, SNRI, pregabalin
58
second line GAD
buspirone
59
last line
BDZ
60
OCD first line
SSRI
61
SAD first line
SSRI, venlafaxine
62
PTSD first line
fluoxetine, sertraline
63
PTSD second
venlafaxine

Pharmacology (33 decks)

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