Flashcards in Anti depressants Deck (63)
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1
Depression Symptom pneumonic
SIGECAPS- sleep, interest, guilt, energy, concentration, appetite, psychomotor, suicidal
2
Serotonin Syndrome
mental status changes, autonomic instablity, neuromuscular aberrations, GI symptoms, ocular clonus, mydriasis
3
SSRI MOA
blocks presynaptic serotonin transporter, leaves serotonin available for use
4
SSRI ADR
NV, insomnia, weight gain, HA, Bruxism, Erectile dysfunction, diaphoresis, Orthostatis, Akathasia, Osteopenia, GI Bleed, some anticholinergic
5
SSRI and pregnancy
some cardiac defects in 1st trimester, low birth weight, permaturity, neonatal withdrawal, pulmonary hypertension in 3rd trimester
6
SSRIs
Fluvoxamine, Fluoxetine, Paroxetine, Citalopram, Escitalopram, Sertraline, Vortioxetine
7
Fluoxetine
MDD, OCD, PD, bulimia
8
Fluoxetine drug interactions
CYP2d6 inhibitor
9
Paroxetine
MDD, OCD, SAD, GAD
10
Paroxetine peals
most sedating, most weight gain, sexual dysfunction, anticholinergic AE
11
Sertraline
MDD, OCD, PD, PTSD, PMDD, SAD
12
Sertraline pearls
fewer drug interactions, good for CV disease
13
Sertraline ADR
dry mouth, sedation, insomnia, tremor, dizziness, sexual dysfunction
14
Escitalopram
MDD, GAD
15
Escitalopram ADR
N, sedation, insomnia, sexual side effects
16
Citalopram pearls
lowest sexual side effects
17
SNRIs MOA
serontonin neuroepi repuptake inhibitors. Bind 5-HT and NE transporter
18
SNRI indications
depression, anxiety disorder, neuropathic pain, chronic pain, fibromyalgia
19
SNRI ADR
HTN, hyperlipidemia, dry mouth, HA, sexual dysfunction, insomnia, NV, akathasia, diaphoresis, weight changes
20
SNRI drug interactions
other serotonin drugs, MAOIS, platelet inhibitors, strong 3A4 inhibitors, 2D6 inhibitors
21
SNRIs
Venlafaxine, Desvenlafaxine, duloxetine, Milnacipran, levomilnacipran.
22
Mirtazipine
major depressive disorder
23
Mirtazipine MOA
increases central NE and 5-HT activity. 5-HT antagonist,
24
Mirtazipine ADR
sedation, somnolence, dizziness, orthostasis, weight gain, elevated cholesterol and LFT, agranulocytosis
25
Bupropion
MDD, smoking cessation
26
Bupropion MOA
weak NE and DA reuptake inhibitor
27
Bupropion ADR
agitation, anxiety, weight loss, insomnia, psychosis, hallucinations, HTN, NV, HA, dry mouth
28
Bupropion contraindications
Seizure disorders
29
Tricyclic antidepressants MOA
SNRI, anitcholinergic, alpha-adrenergic, membrane stabilizing on myocardium
30
