Flashcards in recitation 6.21 Deck (103)
Loading flashcards...
1
Ziconotide
indicated for intrathecal admin for severe chronic pain
2
Ziconotide MOA
N-type calcium channel blocker in primary nociceptors in the dorsal horn
3
Ziconotide Warnings
neuropyschosis
4
Ziconotide ADR
dizziness, ataxia, somnolence, nausea
5
intrathecal baclofen
severe spasticity
6
Intrathecal Baclofen ADR
hypotonia, somnolence, dizziness,
7
Topical analgesics
methyl salicylate, Trolamaine salicylate
8
Counter irritants
menthol, camphor, capsaicin
9
Counter irritants ADR
creates irritation/inflammation locally to relieve inflammation in underlying or adjacent tissues and local anesthetic action
10
Menthol indications
orally for GI complaints and topically for pain, inflammation
11
Menthol ADR
oral: heartburn, NV. Topical: dermatitis, irritation
12
Camphor
topical anti-tussive, analgesic
13
Camphor toxicity
NV, burning of mouth, and throat. can lead to seizure and respiratory depression
14
Capsaicin MOA
TRPV 1 channel agonist. enhances TRPV1 stimulation and relieves pain when these receptors are desensitized.
15
Capsaicin indications
post herpetic neuralgia
16
Capsaicin ADR
oral- GI discomfort, sweating, flushing, anitcoag
Topical- burning, stinging, erythema
17
Iontophoresis
ion current to deliver charged drugs through the skin
18
Gout
allopurinol, colchicine, febuxostat, probenacid, Rasburicase, pegloticase
19
Allopurinol MOA
Xanthine oxidase inhibitor and purine analog. Reduces production of uric acid
20
Allopurinol indications
Chronic treatment of rimary or secondary gout, tumor lysis syndrome in chemo patients, hyperuricemia with recurrent calcium oxalate stones
21
Allopurinol Drug interactions
Azothioprine, warfarin, increases theophylline
22
Allopurinol ADR
rash, ND, increased LFT, acute gout attack
23
Probenacid
chronic treatment for hyperuricemia associated with gout and boosts PSN levels
24
Probenacid MOA
blocks renal tubular reabsorption of urate
25
Probenacid ADR
HA, nausea, worsening gout flares, dizziness, uric acid, kidney stones, blood dyscrasias
26
Febuxostat
chronic treatment for gout
27
Febuxostat MOA
Xanthine oxidase inhibitor
28
Febuxostat ADR
higher CV events and hepatic failure
29
Lesinurad
use with an XOI when target uric acid levels are not acheived
30
