recitation 6.21 Flashcards Preview

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Flashcards in recitation 6.21 Deck (103)
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1

Ziconotide

indicated for intrathecal admin for severe chronic pain

2

Ziconotide MOA

N-type calcium channel blocker in primary nociceptors in the dorsal horn

3

Ziconotide Warnings

neuropyschosis

4

Ziconotide ADR

dizziness, ataxia, somnolence, nausea

5

intrathecal baclofen

severe spasticity

6

Intrathecal Baclofen ADR

hypotonia, somnolence, dizziness,

7

Topical analgesics

methyl salicylate, Trolamaine salicylate

8

Counter irritants

menthol, camphor, capsaicin

9

Counter irritants ADR

creates irritation/inflammation locally to relieve inflammation in underlying or adjacent tissues and local anesthetic action

10

Menthol indications

orally for GI complaints and topically for pain, inflammation

11

Menthol ADR

oral: heartburn, NV. Topical: dermatitis, irritation

12

Camphor

topical anti-tussive, analgesic

13

Camphor toxicity

NV, burning of mouth, and throat. can lead to seizure and respiratory depression

14

Capsaicin MOA

TRPV 1 channel agonist. enhances TRPV1 stimulation and relieves pain when these receptors are desensitized.

15

Capsaicin indications

post herpetic neuralgia

16

Capsaicin ADR

oral- GI discomfort, sweating, flushing, anitcoag
Topical- burning, stinging, erythema

17

Iontophoresis

ion current to deliver charged drugs through the skin

18

Gout

allopurinol, colchicine, febuxostat, probenacid, Rasburicase, pegloticase

19

Allopurinol MOA

Xanthine oxidase inhibitor and purine analog. Reduces production of uric acid

20

Allopurinol indications

Chronic treatment of rimary or secondary gout, tumor lysis syndrome in chemo patients, hyperuricemia with recurrent calcium oxalate stones

21

Allopurinol Drug interactions

Azothioprine, warfarin, increases theophylline

22

Allopurinol ADR

rash, ND, increased LFT, acute gout attack

23

Probenacid

chronic treatment for hyperuricemia associated with gout and boosts PSN levels

24

Probenacid MOA

blocks renal tubular reabsorption of urate

25

Probenacid ADR

HA, nausea, worsening gout flares, dizziness, uric acid, kidney stones, blood dyscrasias

26

Febuxostat

chronic treatment for gout

27

Febuxostat MOA

Xanthine oxidase inhibitor

28

Febuxostat ADR

higher CV events and hepatic failure

29

Lesinurad

use with an XOI when target uric acid levels are not acheived

30

Lesinurad MOA

blocks uric acid resborption