Flashcards in Anti-epileptic Deck (88):
1
Carbamazepine
First line for partial seizures
2
Oxcarbazepine
first line for partial seizures
3
Lamotrigine
adjunct for focal, tonic clonic, absence. second line bipolar and lennox gastaut
4
Valproic Acid
Focal seizures, generalized tonic clonic mixed seizures, absence, migraine, bipolar
5
Levitiracetam
focal seizures, myoclonic, primary generalized tonic clonic
6
Lacosamide
adjunct focal
7
Zonisamide
Adjunct focal
8
Perampanel
second line focal seizures, generalized tonic-clonic
9
Phenobarbital
second line short term sedative, generalized and focal seizures, lennox-gastuat syndrome. First line status epilepticus
10
Primidone
generalized tonic clonic, psychomotor, focal seizures
11
Gabapentin
peripheral neuropathy, bipolar disorder
12
pregablin
diabetic peripheral neuropathy, postherpetic neuralgia, adjunct for focal seizures, fibromyalgia, neuropathic pain from spinal cord injury
13
Exogabine
adjunct for focal
14
Felbamate
refractory partial seizures, lennox gastaut
15
Eslicarbazepine
monotherapy for partial onset seizures
16
Topiramate
focal seizures, generalized tonic clonic, lennox-gastaut, migraine prophylaxis, weight loss
17
Ethosuximide
absence seizures
18
Phenytoin
generalized tonic-clonic, focal
19
Fosphenytoin
status epilepticus
20
Clonezepam
lennox gastaut, second line absence
21
Diazepam
first line status epilepticus
22
Lorazepam
status epilepticus
23
midazolam IV
status epileptics
24
Clobazam
adjunct for lennox gastuat
25
Tiagabine
adjunct therapy in pts 12 and older for focal seizures
26
Brivaracetam
adjunct treatment for partial onset seizures
27
Carbamazepine MOA
inhibits Na channels
28
Carbamazepine contraindications
bone marrow suppression, use of MAOI, HLA-B 1502
29
Carbamazepine common ADR
Drowsiness diplopia, HA, ataxia, dizziness, NVD, constipation, abd pain, decreased appetite, leukopenia, hyponatremia, rash
30
Carbamazepine serious ADR
aplastic anemia, hepatitis, pancreatitis, SJS, TEN, preg cat D
31
Oxcarbamazepine MOA
inhibits Na channels
32
Oxcarbamazepine common ADR
sedation, dizziness, diplopia, Ha, nausea,
33
Oxcarbamazepine serious ADR
SJS, TEN, hyponatremia, angioedema, anaphylaxis
34
Lamotrigine MOA
blocks Na channels, enhances H current, modulates kainate receptors
35
Lamotrigine warnings
SJS, DRESS, suicide, aseptic meningitis
36
Lamotrigine interactions
OC, valproate
37
Lamotrigine common ADR
Ha, insomnia, drowsiness, diplopia, ataxia, rash, Nausea
38
Lamotrigine serious ADR
SJS, TEN,
39
Valproic acid MOA
enhanced Gaba transmission, Na channel inhibitor, modulation of T-type calcium channels
40
Valproate contrindications
liver disease, pregnancy
41
Valproate common ADR
NV, fatigue, dizziness, tremor, alopecia, weight gain, depression, hyperammonemia, rirregular periods, bone loss
42
Valproate serious ADR
hepatoxicity, pancreatitis, thrombocytopenia
43
Levetiracetam
binding of SV2a, modulates kainate receptor, reverses GABA inhibition
44
Levetiracetam common ADR
dizziness, somnolence, asthenia, irritabilit
45
Levetiracetam serious ADR
anxiety, agitation
46
Topiramate MOA
blocks Na channels, increases freq at which GABA opens Cl- channels, antagonizes glutamate action, inhibits carbonic anhydrase
47
Topiramate warnings
acute myopia and angle closure glaucoma, oligohidrosis and hyperthermia, metabolic acidosis, nephrolithiasis, suicidal ideation, cleft palate, renal dose adjust
48
Topiramate serious ADR
bullous skin rxn, hepatic failure, maculopathy, glaucoma, pancreatitis, nephrolithiasis, metabolic acidosis, neuropsych decline, osteoporosis
49
Topiramate common ADR
somnolence, ataxia, speech disorders, difficulty with memory, parasthesia, weight loss
50
Topiramate drug interactions
decreased by valproate, phenytoin, carbamazepine, lamotrigine, OC, CNS depressants
51
Ethosuximide MOA
blocks T-type calcium channels
52
Ethosuximide common ADR
NVD, abd discomfort, decreased appetite, drowsiness, dizziness, HA, agitation, pink-brown urine
53
Ethosuximide serious ADR
blood dyscrasias, liver, kidney effects, SLE, SJS, neuropsych
54
Phenytoin MOA
slows recovery of Na channels
55
Phenytoin common ADR
sedation, impaired cognition, slurred speech, nystagmus, decreased coordination, confusion, dizziness, HA
56
Phenytoin serious ADR
osteomalacia, lymphadenopathy, dermatitis
57
Fosphenytoin MOA
prodrug of of phenytoin
58
Zonisamide MOA
blocks Na channels and t type channels, mild carbonic anhydrase inhibitor
59
Zonisamide contraindications
sulfa allergy
60
Zonisamide warnings
SJS, blood dyscrasias, oligohidrosis, hyperthermia, suicide, met acidosis, teratogenicity, kidney stones
61
Zonisamide common ADR
somnolence, fatigue, anorexia, weight loss dizziness, confusion, ataxia, agitation, memory loss
62
Zonisamde serious ADR
nephrolithiasis, leukopenia, oligohidrosis, rash, depression, met acidosis
63
Lacosamide MOA
enhances slow inactivation of Na channels
64
Perampanel MOA
noncompetitive glutamate receptor antagonist
65
Perampanel common ADR
anxiety, confusion, imbalance, diplopia, nausea, weight gain, aggressive behavior, paranoia
66
GABA drugs
barbiturates, benzodiazepines, gabapentin, pregablin, tiagabine, vigabatrin,
67
Phenobarbital MOA
prolong GABA mediated chloride channel opening
68
Phenobarbital warnings
addictive, hyperalgesia, pregnancy, peds, EtOH, respiratory depression
69
Phenobarbital common ADR
CNS depressant, depression, hyperactivity, impaired attention, dizziness, decreased libido, erectile dysfunction, nausea, foalte def, anemia, rash, fever, bone loss, hypocalcemia
70
Primidone MOA
metabolized to phenobarbital
71
Primidone ADR
ataxia, NV, diplopia
72
Benzodiazepine MIA
increase freq of GABA mediated chloride channel opening
73
Gabapentin MOA
blocks Ca channels, enhances H current, suppresses presynaptic vesicle release, suppresses NMDA receptors
74
Gabapentin ADR
sedation, somnolence, dizziness, weight gain
75
Pregablain MOA
son of gabapentin
76
Pregabalin ADR
angioedema, peripheral edema, weight gain, somnolence, dizziness
77
Tiagabine MOA
interferes with GABA reuptake
78
Tiagabine warnings
new onset seizures
79
Vigabatrin MOA
GABA analog. irreversibly inhibits GABA transaminase
80
Vigabatrin ADR
vision loss
81
Ezogabine MOA
opens potassium channels
82
Ezogabine ADR
dizziness, somnolence, confusion, hallucinations, blue skin, retinal pigment changes, urinary retention
83
Felbamate MOA
blocks Na channels and modulate NMDA and GABA receptors
84
Felbamate ADR
last line due to risk of aplastic anemia and acute hepatic failure
85
Eslicarbazepine serious ADR
SJS, TEN, DRESS, anaphylaxis, hyponatremia, elevated LFT, thyroid function,
86
Eslicarbazepine common ADR
vertigo, vision changes, NV, fatigue, dizziness, HA, ataxia, balance disorder
87
Eslicarbazepine drug interactions
OC, warfarin, statins
88