Anti-epileptic Flashcards Preview

Pharmacology > Anti-epileptic > Flashcards

Flashcards in Anti-epileptic Deck (88):
1

Carbamazepine

First line for partial seizures

2

Oxcarbazepine

first line for partial seizures

3

Lamotrigine

adjunct for focal, tonic clonic, absence. second line bipolar and lennox gastaut

4

Valproic Acid

Focal seizures, generalized tonic clonic mixed seizures, absence, migraine, bipolar

5

Levitiracetam

focal seizures, myoclonic, primary generalized tonic clonic

6

Lacosamide

adjunct focal

7

Zonisamide

Adjunct focal

8

Perampanel

second line focal seizures, generalized tonic-clonic

9

Phenobarbital

second line short term sedative, generalized and focal seizures, lennox-gastuat syndrome. First line status epilepticus

10

Primidone

generalized tonic clonic, psychomotor, focal seizures

11

Gabapentin

peripheral neuropathy, bipolar disorder

12

pregablin

diabetic peripheral neuropathy, postherpetic neuralgia, adjunct for focal seizures, fibromyalgia, neuropathic pain from spinal cord injury

13

Exogabine

adjunct for focal

14

Felbamate

refractory partial seizures, lennox gastaut

15

Eslicarbazepine

monotherapy for partial onset seizures

16

Topiramate

focal seizures, generalized tonic clonic, lennox-gastaut, migraine prophylaxis, weight loss

17

Ethosuximide

absence seizures

18

Phenytoin

generalized tonic-clonic, focal

19

Fosphenytoin

status epilepticus

20

Clonezepam

lennox gastaut, second line absence

21

Diazepam

first line status epilepticus

22

Lorazepam

status epilepticus

23

midazolam IV

status epileptics

24

Clobazam

adjunct for lennox gastuat

25

Tiagabine

adjunct therapy in pts 12 and older for focal seizures

26

Brivaracetam

adjunct treatment for partial onset seizures

27

Carbamazepine MOA

inhibits Na channels

28

Carbamazepine contraindications

bone marrow suppression, use of MAOI, HLA-B 1502

29

Carbamazepine common ADR

Drowsiness diplopia, HA, ataxia, dizziness, NVD, constipation, abd pain, decreased appetite, leukopenia, hyponatremia, rash

30

Carbamazepine serious ADR

aplastic anemia, hepatitis, pancreatitis, SJS, TEN, preg cat D

31

Oxcarbamazepine MOA

inhibits Na channels

32

Oxcarbamazepine common ADR

sedation, dizziness, diplopia, Ha, nausea,

33

Oxcarbamazepine serious ADR

SJS, TEN, hyponatremia, angioedema, anaphylaxis

34

Lamotrigine MOA

blocks Na channels, enhances H current, modulates kainate receptors

35

Lamotrigine warnings

SJS, DRESS, suicide, aseptic meningitis

36

Lamotrigine interactions

OC, valproate

37

Lamotrigine common ADR

Ha, insomnia, drowsiness, diplopia, ataxia, rash, Nausea

38

Lamotrigine serious ADR

SJS, TEN,

39

Valproic acid MOA

enhanced Gaba transmission, Na channel inhibitor, modulation of T-type calcium channels

40

Valproate contrindications

liver disease, pregnancy

41

Valproate common ADR

NV, fatigue, dizziness, tremor, alopecia, weight gain, depression, hyperammonemia, rirregular periods, bone loss

42

Valproate serious ADR

hepatoxicity, pancreatitis, thrombocytopenia

43

Levetiracetam

binding of SV2a, modulates kainate receptor, reverses GABA inhibition

44

Levetiracetam common ADR

dizziness, somnolence, asthenia, irritabilit

45

Levetiracetam serious ADR

anxiety, agitation

46

Topiramate MOA

blocks Na channels, increases freq at which GABA opens Cl- channels, antagonizes glutamate action, inhibits carbonic anhydrase

47

Topiramate warnings

acute myopia and angle closure glaucoma, oligohidrosis and hyperthermia, metabolic acidosis, nephrolithiasis, suicidal ideation, cleft palate, renal dose adjust

48

Topiramate serious ADR

bullous skin rxn, hepatic failure, maculopathy, glaucoma, pancreatitis, nephrolithiasis, metabolic acidosis, neuropsych decline, osteoporosis

49

Topiramate common ADR

somnolence, ataxia, speech disorders, difficulty with memory, parasthesia, weight loss

50

Topiramate drug interactions

decreased by valproate, phenytoin, carbamazepine, lamotrigine, OC, CNS depressants

51

Ethosuximide MOA

blocks T-type calcium channels

52

Ethosuximide common ADR

NVD, abd discomfort, decreased appetite, drowsiness, dizziness, HA, agitation, pink-brown urine

53

Ethosuximide serious ADR

blood dyscrasias, liver, kidney effects, SLE, SJS, neuropsych

54

Phenytoin MOA

slows recovery of Na channels

55

Phenytoin common ADR

sedation, impaired cognition, slurred speech, nystagmus, decreased coordination, confusion, dizziness, HA

56

Phenytoin serious ADR

osteomalacia, lymphadenopathy, dermatitis

57

Fosphenytoin MOA

prodrug of of phenytoin

58

Zonisamide MOA

blocks Na channels and t type channels, mild carbonic anhydrase inhibitor

59

Zonisamide contraindications

sulfa allergy

60

Zonisamide warnings

SJS, blood dyscrasias, oligohidrosis, hyperthermia, suicide, met acidosis, teratogenicity, kidney stones

61

Zonisamide common ADR

somnolence, fatigue, anorexia, weight loss dizziness, confusion, ataxia, agitation, memory loss

62

Zonisamde serious ADR

nephrolithiasis, leukopenia, oligohidrosis, rash, depression, met acidosis

63

Lacosamide MOA

enhances slow inactivation of Na channels

64

Perampanel MOA

noncompetitive glutamate receptor antagonist

65

Perampanel common ADR

anxiety, confusion, imbalance, diplopia, nausea, weight gain, aggressive behavior, paranoia

66

GABA drugs

barbiturates, benzodiazepines, gabapentin, pregablin, tiagabine, vigabatrin,

67

Phenobarbital MOA

prolong GABA mediated chloride channel opening

68

Phenobarbital warnings

addictive, hyperalgesia, pregnancy, peds, EtOH, respiratory depression

69

Phenobarbital common ADR

CNS depressant, depression, hyperactivity, impaired attention, dizziness, decreased libido, erectile dysfunction, nausea, foalte def, anemia, rash, fever, bone loss, hypocalcemia

70

Primidone MOA

metabolized to phenobarbital

71

Primidone ADR

ataxia, NV, diplopia

72

Benzodiazepine MIA

increase freq of GABA mediated chloride channel opening

73

Gabapentin MOA

blocks Ca channels, enhances H current, suppresses presynaptic vesicle release, suppresses NMDA receptors

74

Gabapentin ADR

sedation, somnolence, dizziness, weight gain

75

Pregablain MOA

son of gabapentin

76

Pregabalin ADR

angioedema, peripheral edema, weight gain, somnolence, dizziness

77

Tiagabine MOA

interferes with GABA reuptake

78

Tiagabine warnings

new onset seizures

79

Vigabatrin MOA

GABA analog. irreversibly inhibits GABA transaminase

80

Vigabatrin ADR

vision loss

81

Ezogabine MOA

opens potassium channels

82

Ezogabine ADR

dizziness, somnolence, confusion, hallucinations, blue skin, retinal pigment changes, urinary retention

83

Felbamate MOA

blocks Na channels and modulate NMDA and GABA receptors

84

Felbamate ADR

last line due to risk of aplastic anemia and acute hepatic failure

85

Eslicarbazepine serious ADR

SJS, TEN, DRESS, anaphylaxis, hyponatremia, elevated LFT, thyroid function,

86

Eslicarbazepine common ADR

vertigo, vision changes, NV, fatigue, dizziness, HA, ataxia, balance disorder

87

Eslicarbazepine drug interactions

OC, warfarin, statins

88

Brivaracetam ADR

somnolence, dizziness, fatigue, NV