Neuro Drugs Flashcards Preview

Pharmacology > Neuro Drugs > Flashcards

Flashcards in Neuro Drugs Deck (45):
1

Pyridostigmine

Myasthenia gravis. Acetycholinesterase inhibitor

2

Neostigmine

myasthenia gravis. Acetylcholinesterase inhibitor

3

Acetylcholinesterase inhibitor ADR

Cholinergic crisis, rash, NVD, adb cramps, increased salivation, increased bronchial secretions, muscle cramps, weakness

4

Riluzole

ALS

5

Riluzole ADR

NVD, asthenia, dizziness, decreased lung function, abd pain, pneumonia, vertigo, parasthesia, anorexia, somnolence

6

Tetrabenazine

Chorea

7

Tetrabenazine ADR

depression, fatigue, insomnia, dizziness, akathisia

8

Interferon Beta

Multiple sclerosis

9

Glatiramer acetate

MS.

10

Dimethyl fumurate

MS.

11

IVIg

MS.

12

Mitoxantrone

MS.

13

Natalizumab

MS.

14

Fingolimod

MS.

15

Teriflunomide

MS.

16

Dalfampridine

walking in MS.

17

Dantrolene

muscle relaxant for MS and malignant hyperthermia

18

Nuedexta

pseudobulbar affect in MS

19

Oral MS drugs

Dimethyl fumurate, Fingolimod, Teriflunomide, dalfampridine

20

Injectable MS

Interferon beta, IVIg, Mitoxantrone, Natalizumab, dantrolene, neudexta

21

interferon beta MOA

immunomodulator, anitviral, antiproliferative

22

Interferon beta warnings

depression, suicide, psychotic disorders, hepatoxicity, new autoimmune disorders, CHF, blood dyscrasias, seizures

23

interferon beta ADR

flu like symptoms, insomnia, injxn site reaction, peripheral edema, malaise, HTN, incoordination

24

Glatiramer acetate MOA

immunomodulator

25

Glatiramer acetate warnings

post injection reaction- flushing, chest tightness, palpitations, dyspnea, throat constriction

26

Glatiramer acetate ADR

vasodilation, rash, dyspnea, chest pain, anxiety, diaphoresis, nausea, pain, weakness, infection

27

Mitoxantrone MOA

antineoplastic, inhibits topoisomerase, T cells and B cells

28

Mitoxantrone warnings

myelosuppression, cardiotoxicity, secondary AML

29

Mitoxantrone ADR

nausea, alopecia, menstrual changes, URI, UTI, blue-green urine, preg cat D

30

Natalizumab MOA

binds leukocytes and inhibits adhesion

31

Natalizumab warnings

progressive multifocal leukoencephalopathy

32

Dimethyl fumurate ADR

leukopenia, flushing, rash, NVD, abd pain, indigestion

33

fingolimod MOa

keeps WBC inside lymph nodes so they don't cross BBB into CNS

34

Fingolimod ADR

first dose bradycardia, varicella zoster, increased mortality, PML, HA, flu, diarrhea, back pain, abnormal LFT, cough

35

Teriflunomide MOA

pyrimidine synthesis inhibitor. inhibits immune cells

36

Teriflunomide ADR

hepatoxic, teratogenic, bone marrow suppression, peripheral neuropathy, hyperkalemia, transient renal failure, ND, abnormal LFT, flu, alopecia

37

Dalfampridine MOA

calcium channel blocker

38

Dalfampridine contraindications

renal impairment and seizures

39

Dantrolene contraindications

liver disease

40

Dantrolene ADR

drowsiness, dizziness, malaise, diarrhea

41

Neudexta MOA

dextramethorphan- NMDA receptor antagonist and quinidine increases bioavailability of dextramethorphan

42

neudexta contraindications

long qt, AV block

43

Neudexta ADR

NVD, cough, liver

44

Pyridostigmine contraindications

urinary or bowel obstruction, Asthma/COPD

45

Pyridostigmine ADR

cholinergic crisis, rash, NVD, cramps, peristalsis, salivation, bronchial secretions, diaphoresis, muscle cramps, fasiculation, weakness