Neuro Drugs

Question 1

Pyridostigmine

Answer 1

Myasthenia gravis. Acetycholinesterase inhibitor

Question 2

Neostigmine

Answer 2

myasthenia gravis. Acetylcholinesterase inhibitor

Question 3

Acetylcholinesterase inhibitor ADR

Answer 3

Cholinergic crisis, rash, NVD, adb cramps, increased salivation, increased bronchial secretions, muscle cramps, weakness

Question 4

Riluzole

Answer 4

ALS

Question 5

Riluzole ADR

Answer 5

NVD, asthenia, dizziness, decreased lung function, abd pain, pneumonia, vertigo, parasthesia, anorexia, somnolence

Question 6

Tetrabenazine

Answer 6

Chorea

Question 7

Tetrabenazine ADR

Answer 7

depression, fatigue, insomnia, dizziness, akathisia

Question 8

Interferon Beta

Answer 8

Multiple sclerosis

Question 9

Glatiramer acetate

Answer 9

MS.

Question 10

Dimethyl fumurate

Answer 10

MS.

Question 11

IVIg

Answer 11

MS.

Question 12

Mitoxantrone

Answer 12

MS.

Question 13

Natalizumab

Answer 13

MS.

Question 14

Fingolimod

Answer 14

MS.

Question 15

Teriflunomide

Answer 15

MS.

Question 16

Dalfampridine

Answer 16

walking in MS.

Question 17

Dantrolene

Answer 17

muscle relaxant for MS and malignant hyperthermia

Question 18

Nuedexta

Answer 18

pseudobulbar affect in MS

Question 19

Oral MS drugs

Answer 19

Dimethyl fumurate, Fingolimod, Teriflunomide, dalfampridine

Question 20

Injectable MS

Answer 20

Interferon beta, IVIg, Mitoxantrone, Natalizumab, dantrolene, neudexta

Question 21

interferon beta MOA

Answer 21

immunomodulator, anitviral, antiproliferative

Question 22

Interferon beta warnings

Answer 22

depression, suicide, psychotic disorders, hepatoxicity, new autoimmune disorders, CHF, blood dyscrasias, seizures

Question 23

interferon beta ADR

Answer 23

flu like symptoms, insomnia, injxn site reaction, peripheral edema, malaise, HTN, incoordination

Question 24

Glatiramer acetate MOA

Answer 24

immunomodulator

Question 25

Glatiramer acetate warnings

Answer 25

post injection reaction- flushing, chest tightness, palpitations, dyspnea, throat constriction

Question 26

Glatiramer acetate ADR

Answer 26

vasodilation, rash, dyspnea, chest pain, anxiety, diaphoresis, nausea, pain, weakness, infection

Question 27

Mitoxantrone MOA

Answer 27

antineoplastic, inhibits topoisomerase, T cells and B cells

Question 28

Mitoxantrone warnings

Answer 28

myelosuppression, cardiotoxicity, secondary AML

Question 29

Mitoxantrone ADR

Answer 29

nausea, alopecia, menstrual changes, URI, UTI, blue-green urine, preg cat D

Question 30

Natalizumab MOA

Answer 30

binds leukocytes and inhibits adhesion

Question 31

Natalizumab warnings

Answer 31

progressive multifocal leukoencephalopathy

Question 32

Dimethyl fumurate ADR

Answer 32

leukopenia, flushing, rash, NVD, abd pain, indigestion

Question 33

fingolimod MOa

Answer 33

keeps WBC inside lymph nodes so they don't cross BBB into CNS

Question 34

Fingolimod ADR

Answer 34

first dose bradycardia, varicella zoster, increased mortality, PML, HA, flu, diarrhea, back pain, abnormal LFT, cough

Question 35

Teriflunomide MOA

Answer 35

pyrimidine synthesis inhibitor. inhibits immune cells

Question 36

Teriflunomide ADR

Answer 36

hepatoxic, teratogenic, bone marrow suppression, peripheral neuropathy, hyperkalemia, transient renal failure, ND, abnormal LFT, flu, alopecia

Question 37

Dalfampridine MOA

Answer 37

calcium channel blocker

Question 38

Dalfampridine contraindications

Answer 38

renal impairment and seizures

Question 39

Dantrolene contraindications

Answer 39

liver disease

Question 40

Dantrolene ADR

Answer 40

drowsiness, dizziness, malaise, diarrhea

Question 41

Neudexta MOA

Answer 41

dextramethorphan- NMDA receptor antagonist and quinidine increases bioavailability of dextramethorphan

Question 42

neudexta contraindications

Answer 42

long qt, AV block

Question 43

Neudexta ADR

Answer 43

NVD, cough, liver

Question 44

Pyridostigmine contraindications

Answer 44

urinary or bowel obstruction, Asthma/COPD

Question 45

Pyridostigmine ADR

Answer 45

cholinergic crisis, rash, NVD, cramps, peristalsis, salivation, bronchial secretions, diaphoresis, muscle cramps, fasiculation, weakness