Flashcards in Neuro Drugs Deck (45):
1
Pyridostigmine
Myasthenia gravis. Acetycholinesterase inhibitor
2
Neostigmine
myasthenia gravis. Acetylcholinesterase inhibitor
3
Acetylcholinesterase inhibitor ADR
Cholinergic crisis, rash, NVD, adb cramps, increased salivation, increased bronchial secretions, muscle cramps, weakness
4
Riluzole
ALS
5
Riluzole ADR
NVD, asthenia, dizziness, decreased lung function, abd pain, pneumonia, vertigo, parasthesia, anorexia, somnolence
6
Tetrabenazine
Chorea
7
Tetrabenazine ADR
depression, fatigue, insomnia, dizziness, akathisia
8
Interferon Beta
Multiple sclerosis
9
Glatiramer acetate
MS.
10
Dimethyl fumurate
MS.
11
IVIg
MS.
12
Mitoxantrone
MS.
13
Natalizumab
MS.
14
Fingolimod
MS.
15
Teriflunomide
MS.
16
Dalfampridine
walking in MS.
17
Dantrolene
muscle relaxant for MS and malignant hyperthermia
18
Nuedexta
pseudobulbar affect in MS
19
Oral MS drugs
Dimethyl fumurate, Fingolimod, Teriflunomide, dalfampridine
20
Injectable MS
Interferon beta, IVIg, Mitoxantrone, Natalizumab, dantrolene, neudexta
21
interferon beta MOA
immunomodulator, anitviral, antiproliferative
22
Interferon beta warnings
depression, suicide, psychotic disorders, hepatoxicity, new autoimmune disorders, CHF, blood dyscrasias, seizures
23
interferon beta ADR
flu like symptoms, insomnia, injxn site reaction, peripheral edema, malaise, HTN, incoordination
24
Glatiramer acetate MOA
immunomodulator
25
Glatiramer acetate warnings
post injection reaction- flushing, chest tightness, palpitations, dyspnea, throat constriction
26
Glatiramer acetate ADR
vasodilation, rash, dyspnea, chest pain, anxiety, diaphoresis, nausea, pain, weakness, infection
27
Mitoxantrone MOA
antineoplastic, inhibits topoisomerase, T cells and B cells
28
Mitoxantrone warnings
myelosuppression, cardiotoxicity, secondary AML
29
Mitoxantrone ADR
nausea, alopecia, menstrual changes, URI, UTI, blue-green urine, preg cat D
30
Natalizumab MOA
binds leukocytes and inhibits adhesion
31
Natalizumab warnings
progressive multifocal leukoencephalopathy
32
Dimethyl fumurate ADR
leukopenia, flushing, rash, NVD, abd pain, indigestion
33
fingolimod MOa
keeps WBC inside lymph nodes so they don't cross BBB into CNS
34
Fingolimod ADR
first dose bradycardia, varicella zoster, increased mortality, PML, HA, flu, diarrhea, back pain, abnormal LFT, cough
35
Teriflunomide MOA
pyrimidine synthesis inhibitor. inhibits immune cells
36
Teriflunomide ADR
hepatoxic, teratogenic, bone marrow suppression, peripheral neuropathy, hyperkalemia, transient renal failure, ND, abnormal LFT, flu, alopecia
37
Dalfampridine MOA
calcium channel blocker
38
Dalfampridine contraindications
renal impairment and seizures
39
Dantrolene contraindications
liver disease
40
Dantrolene ADR
drowsiness, dizziness, malaise, diarrhea
41
Neudexta MOA
dextramethorphan- NMDA receptor antagonist and quinidine increases bioavailability of dextramethorphan
42
neudexta contraindications
long qt, AV block
43
Neudexta ADR
NVD, cough, liver
44
Pyridostigmine contraindications
urinary or bowel obstruction, Asthma/COPD
45