antitumor ab

Question 1

where in the cell cycle do the anti tumor antibiotics work ?

Answer 1

in the g2 m phase
except dactinomycin

Question 2

what are the three groups of antitumor antibiotics ?

Answer 2

bleomycin
dactinomycin
anthracyclines

Question 3

what are the MOA of bleomycin and anthracyclines ?

Answer 3

both induce free radical formation , intercalate in the DNA and cayse DNA breakage

Question 4

what enzyme is inhibited by anthracyclines ?

Answer 4

topoisomerase IIwha

Question 5

what is the side effect associated with anthracyclines ?

Answer 5

dilated cardiomyopathy

Question 6

how can the side effect of anthracyclines be prevented ?

Answer 6

dexrazoxane - an iron chelating agent

Question 7

what are the clinical uses for each type of anti tumor ab?

Answer 7

bleomycin - testicular cancer, hodgkin lymphoma
dactinomycin - wilms tumor , ewing sarcoma , rhabdomyosarcoma ( childhood cancers)
anthracyclines - solid tumors and leukemia

Question 8

what enzymes is inhibited by 6MP ?

Answer 8

PRPP

Question 9

what are examples of the anthracylines ?

Answer 9

doxorubicin
danorubicin

Question 10

what are the toxicities associated with bleomycin ?

Answer 10

skin toxicities and pulmo fibrosis