DNA drugs

Question 1

what are the platinum compounds ?

Answer 1

cisplatin carboplatin and oxaliplatin

Question 2

what is the mechanism of of the platinum compounds ?

Answer 2

they cross link DNA , cell cycle non specific

Question 3

what are the adverse effects associated with platinum compounds ?

Answer 3

nephrotoxicity - fanconi syndroma
peripheral neuropathy
ototoxicity

Question 4

how can nephrotoxicity caused by platinum compounds be avoided ?

Answer 4

amifostine

Question 5

what are the clinical uses of platinum agenst ?

Answer 5

solid tumors and leukemias

Question 6

which of the platinum compounds are associated with a lower risk of renal toxicity ?

Answer 6

carboplatin

Question 7

what are the functions of topoisomerase 1 vs 2?

Answer 7

topoisomerase 1 is associated with cutting a single DNA strand
topoisomerase 2 is associated with cutting both DNA strands

Question 8

what are the topoisomerase 1 inhibitors ?

Answer 8

irinotecan , topotecan

Question 9

what are the topoisomerase 2 inhibitors ?

Answer 9

etoposide
teniposide

Question 10

what are the clinical uses of topoisomerase 1 inhibitors ?

Answer 10

colon cancer
small cell lung cancer

Question 11

what are the clinical uses of topoisomerase 2 inhibitors ?

Answer 11

testicular cancers , small cell lung cancers
leukemia
lymphoma

Question 12

what are the side effects associated with topoisomerase 1 vs 2?

Answer 12

topoisomerase 1 - severe myelosuppression diarrhea
topoisomerase 2 - myelosuppression and alopecia