non hodgkin lymphoma Flashcards
(30 cards)
what ring of lymph nodes is associated with non hodgkin lymphoma ?
waldeyer’s ring in the pharynx
what is the most common non hodgkin lymphoma ?
diffuse large b cell lymphoma which is associated with CLL
what are the CD expression in diffuse large b cell lymphoma ?
CD 19 and CD 20
what is the common case scenario associated with diffuse large b cell lymphoma ?
occurs in patients who have HIV
what is the treatment for diffuse large b cell lymphoma ?
treated with rituximab which is an anti CD 20 drug
what is the drug used against CD20 ?
rituximab , used in B cell lymphoma
what is a follicular lymphoma and what is the genetic association with it ?
a b cell malignancy , a non hodgkin lymphoma
associated with t(14:18)
of heavy chain Ig (14 ) and BCL-2 (18)
germinal centre B cells usually lack Bcl2
what is the clinical presentation associated with follicular lymphoma ?
waxinig and weaning presentation indolent course with painless lymphadenopaty
what does Bcl-2 normally do ?
inhibits apoptosis by stabilizing the mitochondrial membrane , preventing the release of cytochrome c
what mutation is associated with DLBCL ?
Bcl-2 Bcl-6
what is the difference between follicular lymphoma vs reactive lymphoma ?
both show follicular growth
there is somatic hypermutation in the B cells
which means theres macrophages, they have tingible bodies , which is not seen in a follicular lymphoma
what are the genetic mutations associated with mantle cell lymphoma ?
t(11;14) translocation of cyclin D1 and heavy chain Ig
overexpression of cyclin D no halting in the cell cycle
what CD is expressed in mantle cell lymphoma ?
CD5
what is the typical presentation associated with mantle cell lymphoma ?
associated with a very aggressive presentation , patients usually present at a very late stage
what are the genetics associated with marginal cell lymphoma ?
t(11;18)
what are the associations of marginal cell lymphoma ?
associated with chronic inflammation
sjogren syndrome - salivary glands
chronic gastritis
MALT lymphoma - which may regress with h pylori treatment
what is SLL ?
small lymphocytic lymphoma is a different expression of CLL , same disease
CD5 positive
the difference is it has a lower lymphocyte count
what is the age group associated with burkitts lymphoma ?
adolescents or young kids
what is the genetic associations of burkitts lymphoma ?
associated with t(8;14)
translocation of the c-myc gene
what infection is commonly associated with burkitts lymphoma ?
EBV
what does burkitts lymphoma look like under the microscope ?
starry sky appearance with sheets of lymphocytes
what is the clinical presentation associated with burkitts lymphoma ?
jaw lesion
or pelvic or abdominal lesion in the sporadic form
what CD does EBV express ?
CD21
what is the function of cmyc aslan ?
a transcription factor
