Flashcards in Autoimmune Diabetes Deck (16):
DM1 incidence decreasing of increasing?
Antibodies play a role in DM1?
Not really, antibodies can't be within cell.
What is level of autoantibodies in preclinical DM1?
increased for years before overt diabetes
risk of DM1 if had one islet with autoantibodies? when is risk higher?
Two or three increases to 80%
median age at seroconversion for DM1?
Adults get DM1?
Yes. Latent autoimmune diabetes
Is DM1 acute process with full islet destruction?
Nope, takes years, patchy process of destruction
B-Islets killed by CD4 or 8?
CD8 via perforin and granzyme B
What is APS-1 syndrome? How does it happen?
Autoimmune polyglandular syndrome
Mutations in AIRE gene
What is IPEX? Immune Dysfunction polyendocrinopathy enteropathy, X-linked? how does it affect DM1
FoxP3 gene mutation controlling Tregs
80% of kids with it develop DM1?
T-cells recognise which part of insulin?
do identical twins both have DM1? what does it mean?
only 30-40% get it if other twin is positive: environmental factors are important in autoimmunity
What's wrong with current DM1 Rx?
can't mimick physiology
risk of hypoglycaemia
Advantage of islet transplantation?
glycemic control, so less hypoglycaemia unawareness
problems with islet transplantation?
need immunosuppressants, cost, longevity viability