Autoimmune Diabetes Flashcards Preview

Jason's Metabolism Block > Autoimmune Diabetes > Flashcards

Flashcards in Autoimmune Diabetes Deck (16):
1

DM1 incidence decreasing of increasing?

increasing

2

Antibodies play a role in DM1?

Not really, antibodies can't be within cell.

3

What is level of autoantibodies in preclinical DM1?

increased for years before overt diabetes

4

risk of DM1 if had one islet with autoantibodies? when is risk higher?

low (12.7%)
Two or three increases to 80%

5

median age at seroconversion for DM1?

2.1 years

6

Adults get DM1?

Yes. Latent autoimmune diabetes

7

Is DM1 acute process with full islet destruction?

Nope, takes years, patchy process of destruction

8

B-Islets killed by CD4 or 8?

CD8 via perforin and granzyme B

9

What is APS-1 syndrome? How does it happen?

Autoimmune polyglandular syndrome
Mutations in AIRE gene

10

What is IPEX? Immune Dysfunction polyendocrinopathy enteropathy, X-linked? how does it affect DM1

FoxP3 gene mutation controlling Tregs
80% of kids with it develop DM1?

11

T-cells recognise which part of insulin?

C-peptide

12

do identical twins both have DM1? what does it mean?

only 30-40% get it if other twin is positive: environmental factors are important in autoimmunity

13

What's wrong with current DM1 Rx?

can't mimick physiology
risk of hypoglycaemia
burdensome

14

Advantage of islet transplantation?

glycemic control, so less hypoglycaemia unawareness

15

problems with islet transplantation?

need immunosuppressants, cost, longevity viability

16

'holy grail' of DM1 treatment?

Antigen specific tolerance