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Jason's Metabolism Block > Drugs used in Obesity > Flashcards

Flashcards in Drugs used in Obesity Deck (27):
0

What are 2 adiposity signals?

Leptin
Insulin

1

What are 2 Satiety signals?

1. CCK
2. Liver Sympathetic

2

What is orexigenic? Example?

increase feeding
Neuropeptide Y

3

What is anorexigenic mean? Example?

decrease feeding
alpha-melanocyte stimulating hormone

4

Both Neuropeptide Y and a-melanocyte stimulating hormone act peripherally or centrally?

centrally

5

4 peripheral peptides that regulate eating?

Ghrelin
Leptin
Insulin
CCK

6

Leptin higher or lower at what time of day?

peaks at lunch
nadir at midnight

7

Leptin crosses BBB how?

actively transported

8

Why is leptin not a good magic pill?

leptin transport is saturable process, so perhaps can't get enough in

9

leptin receptors are where?

hypothalamus

10

leptin levels in obese people are?

high

11

Leptin resistance can happen where? 3 places

1. Hypothalamus receptors
2. 2nd messenger
3. saturated leptin transport system

12

Target what 2 things in fat for obesity? which drugs?

absorption - orlistat
metabolism - lipolysis

13

B3 adrenergic receptor agonists do what?

increase thermogenesis

14

How does Phentermine work?

sympathomimetic amine

15

How long use phentermine for?

3 weeks only

16

how long use orlistat for?

long term use

17

Obesity drugs need to be combined with?

low calorie diet
exercise

18

what does phentermine do to the brain?

increases NA, DA, 5-HT

19

mechanism of phentermine on neurons?

inhibit neuronal uptake

20

phentermine cannot be combined with?

MAO inhibitors
pregnancy

21

Topiramate main 2 uses? off-label?

epilepsy, migraine
off-label: weight loss

22

When to take Orlistat during day?

before meals

23

orlistate mechanism?

bind and block lipase, prevent fat absorption

24

why would orlistat help people change their diet and lose weight?

side effects if have fatty meal is faecal fat leakage and explosive diarrhoea

25

supplementation with orlistat?

yes D & E

26

why only use phentermine for short term?

tolerance
addiction