Flashcards in Drugs used in Obesity Deck (27)
What are 2 adiposity signals?
What are 2 Satiety signals?
2. Liver Sympathetic
What is orexigenic? Example?
What is anorexigenic mean? Example?
alpha-melanocyte stimulating hormone
Both Neuropeptide Y and a-melanocyte stimulating hormone act peripherally or centrally?
4 peripheral peptides that regulate eating?
Leptin higher or lower at what time of day?
peaks at lunch
nadir at midnight
Leptin crosses BBB how?
Why is leptin not a good magic pill?
leptin transport is saturable process, so perhaps can't get enough in
leptin receptors are where?
leptin levels in obese people are?
Leptin resistance can happen where? 3 places
1. Hypothalamus receptors
2. 2nd messenger
3. saturated leptin transport system
Target what 2 things in fat for obesity? which drugs?
absorption - orlistat
metabolism - lipolysis
B3 adrenergic receptor agonists do what?
How does Phentermine work?
How long use phentermine for?
3 weeks only
how long use orlistat for?
long term use
Obesity drugs need to be combined with?
low calorie diet
what does phentermine do to the brain?
increases NA, DA, 5-HT
mechanism of phentermine on neurons?
inhibit neuronal uptake
phentermine cannot be combined with?
Topiramate main 2 uses? off-label?
off-label: weight loss
When to take Orlistat during day?
bind and block lipase, prevent fat absorption
why would orlistat help people change their diet and lose weight?
side effects if have fatty meal is faecal fat leakage and explosive diarrhoea
supplementation with orlistat?
yes D & E