GI Tract in Obesity Flashcards Preview

Jason's Metabolism Block > GI Tract in Obesity > Flashcards

Flashcards in GI Tract in Obesity Deck (30):
1

What 2 things stimulate hunger? (Orexigenic)

Ghrelin
ILP5

2

what is the 'master control' for eating in the brain?

Arcuate Nucleus

3

2 things in Arcuate Nucleus stim appetite:

NPY
AGRP

4

What 5 things decrease hunger?

Uroguanylin
CCK
PYY
GLP-1
Oxyntomodulin

5

Ghrelin made where?

Stomach

6

What does Ghrelin do to Leptin? where?

antagonizes leptin via hypothalamic Y/Y1 receptor

7

Ghrelin binds to what receptor?

NPY Y1 receptor

8

When does Ghrelin rise?

Preprandial

9

ILP-5 made where? what does it do?

colon
increases appetite

10

If you inhibit NPY Y1 receptor, what does it do to Ghrelin?

Can't bind = decrease appetite

11

ILP-5 or ghrelin more powerful?

ghrelin

12

CCK secreted from?

I cells of small intestine

13

CCK's role in digestion?

gall bladder and pancreas stim

14

How does CCK decrease appetite?

CCK1R on vagus nerve

15

PYY made where?

Distal GI by L-cells

16

PYY binds to?

Y2 receptor

17

Oxyntomodulin from which cells?

L-cells

18

Oxyntomodulin affects via? deactivated by?

affects via GLP-1
inactivated by DPP-4

19

Oxyntomodulin or GLP-1 more potent?

Oxyntomodulin

20

L-Cells of intestine release:

1. Oxyntomodulin
2. PYY
3. GLP-1

21

PYY and Oxyntomodulin together?

can be additive

22

GIP is released from?

duodenal K-cells

23

GIP is an?

Incretin

24

GIP does what?

activate lipoprotein lipase to clear fat from circulation

25

GLP-1 is an? effects?

Incretin
decrease appetite
promotes satiety

26

What is liraglutide?

drug for DMII and GLP-1 (incretin mimetic)

27

Uroguanylin does what?

decrease appetite

28

How do gut hormones affect weight?

They defend against weight loss

29

What happens if you give germ free mice microbiota?

Gain more fat than either germ free or naturally acquired microbiota mice

30

MIcrobiota does 2 things to contribute to our fat stores:

1. process dietary polysaccharides
2. supress FIAF (fasting induced adipocyte factor)