Flashcards in GI Tract in Obesity Deck (30)
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1
What 2 things stimulate hunger? (Orexigenic)
Ghrelin
ILP5
2
what is the 'master control' for eating in the brain?
Arcuate Nucleus
3
2 things in Arcuate Nucleus stim appetite:
NPY
AGRP
4
What 5 things decrease hunger?
Uroguanylin
CCK
PYY
GLP-1
Oxyntomodulin
5
Ghrelin made where?
Stomach
6
What does Ghrelin do to Leptin? where?
antagonizes leptin via hypothalamic Y/Y1 receptor
7
Ghrelin binds to what receptor?
NPY Y1 receptor
8
When does Ghrelin rise?
Preprandial
9
ILP-5 made where? what does it do?
colon
increases appetite
10
If you inhibit NPY Y1 receptor, what does it do to Ghrelin?
Can't bind = decrease appetite
11
ILP-5 or ghrelin more powerful?
ghrelin
12
CCK secreted from?
I cells of small intestine
13
CCK's role in digestion?
gall bladder and pancreas stim
14
How does CCK decrease appetite?
CCK1R on vagus nerve
15
PYY made where?
Distal GI by L-cells
16
PYY binds to?
Y2 receptor
17
Oxyntomodulin from which cells?
L-cells
18
Oxyntomodulin affects via? deactivated by?
affects via GLP-1
inactivated by DPP-4
19
Oxyntomodulin or GLP-1 more potent?
Oxyntomodulin
20
L-Cells of intestine release:
1. Oxyntomodulin
2. PYY
3. GLP-1
21
PYY and Oxyntomodulin together?
can be additive
22
GIP is released from?
duodenal K-cells
23
GIP is an?
Incretin
24
GIP does what?
activate lipoprotein lipase to clear fat from circulation
25
GLP-1 is an? effects?
Incretin
decrease appetite
promotes satiety
26
What is liraglutide?
drug for DMII and GLP-1 (incretin mimetic)
27
Uroguanylin does what?
decrease appetite
28
How do gut hormones affect weight?
They defend against weight loss
29
What happens if you give germ free mice microbiota?
Gain more fat than either germ free or naturally acquired microbiota mice
30
