Flashcards in GI Tract in Obesity Deck (30):
What 2 things stimulate hunger? (Orexigenic)
what is the 'master control' for eating in the brain?
2 things in Arcuate Nucleus stim appetite:
What 5 things decrease hunger?
Ghrelin made where?
What does Ghrelin do to Leptin? where?
antagonizes leptin via hypothalamic Y/Y1 receptor
Ghrelin binds to what receptor?
NPY Y1 receptor
When does Ghrelin rise?
ILP-5 made where? what does it do?
If you inhibit NPY Y1 receptor, what does it do to Ghrelin?
Can't bind = decrease appetite
ILP-5 or ghrelin more powerful?
CCK secreted from?
I cells of small intestine
CCK's role in digestion?
gall bladder and pancreas stim
How does CCK decrease appetite?
CCK1R on vagus nerve
PYY made where?
Distal GI by L-cells
PYY binds to?
Oxyntomodulin from which cells?
Oxyntomodulin affects via? deactivated by?
affects via GLP-1
inactivated by DPP-4
Oxyntomodulin or GLP-1 more potent?
L-Cells of intestine release:
PYY and Oxyntomodulin together?
can be additive
GIP is released from?
GIP is an?
GIP does what?
activate lipoprotein lipase to clear fat from circulation
GLP-1 is an? effects?
What is liraglutide?
drug for DMII and GLP-1 (incretin mimetic)
Uroguanylin does what?
How do gut hormones affect weight?
They defend against weight loss
What happens if you give germ free mice microbiota?
Gain more fat than either germ free or naturally acquired microbiota mice