Diabetes Type 1 Management Flashcards Preview

Jason's Metabolism Block > Diabetes Type 1 Management > Flashcards

Flashcards in Diabetes Type 1 Management Deck (24):
1

DM1 presents with?

weight loss
polyuria
polydipsia
ketoacidosis

2

short acting insulin GLARGINE is short or long acting?

long acting

3

Detemir replaces B30 and replaced with?

fatty acid

4

Typical insulin regime?

1. Basal Bolus before bed
2. short acting prior to each meal

5

Insulin pumps deliver?

continuously at back ground rate

6

What is artificial pancreas?

closed loop system

7

what is artificial pancreas good for?

prevention of nocturnal hypoglycaemia

8

2 issues with islet transplantation?

1. availability
2. life-long immunosuppression

9

3 tissues particularly vulnerable to DM1 complications?

Retinopathy
Nephropathy
Neuropathy

10

What should you aim for in glycaemic control?

7 for HB-A1C

11

what is non-enzymatic glycosylation?

binds to RBC proteins irreversibly covalent bonds

12

Why measure HB-A1C?

gives an indirect measure of average levels of blood glucose for past 3 months

13

Why measure fructosamine?

if they have high red cell turn over as they will have low HB-A1C

14

how to measure kidney function in DM1?

urinary microalbumin
creatinine to albumin ratio

15

How test neuropathy in DM1?

sensation testing

16

what is low blood glucose value?

<4mmol/L

17

2 types of hypoglycaemia symptoms?

1. rapid fall: sympathetic discharge
2. absolute low: brain malfunction/coma, death

18

what hormone seems to be the one important factor to get out of hypoglycaemia?

glucagon

19

How to treat conscious hypoglycaemia?

oral glucose then meal

20

how to treat diminished conscious hypoglycaemia?

intravenous glucose or
glucagon

21

if DM1 has no insulin for a day, what happens?

ketoacidosis: hospitalization

22

#1 reason for ketoacidosis in DM1?

infection

23

why give potassium replacement in ketoacidosis?

Insulin pushes K+ into cells > hypokalaemia > arrythmia > death

24

important thing to do if keto in a known diabetic?

reasons behind it