Oral Hyperglycaemic Drugs Flashcards Preview

Jason's Metabolism Block > Oral Hyperglycaemic Drugs > Flashcards

Flashcards in Oral Hyperglycaemic Drugs Deck (22):
1

DMII can't have what after a meal?

insulin burst

2

First DM2 drugs were?

sulphonamide drugs

3

Mechanism of Sulphonylureas?

Inhibit K-ATP channel to cause insulin secretion

4

Sulphonylureas preg? excretion?

Not in preg
excreted in kidney

5

Sulphonylureas weight gain or loss?

gain

6

3 actions of insulin

GLUT 4
PI3-kinase
SHC

7

What is Guanidine?

from french lilac later isolated and medicinalized to Biguanides

8

What is the most used Biguanides?

Metformin

9

4 Metformin actions:

1. increase glucose uptake
2. reduce hepatic glucose production
3. decrease carb absorption
4. reduce LDL

10

What is Metformin's MOA?

activate AMP kinase

11

Sulphonylureas weight gain or loss?

some loss

12

Metformin contraindication?

impaired renal function?

13

Metformin is a?

Biguanide

14

What drugs stims insulin?

Sulfonylureas
meglitinides

15

What drugs sensitize body to insulin?

Biguanides
thiazolidinediones

16

Acarbose is a what?

alpha-glucosidase inhibitor

17

What does Acarbose do?

work in GI
block starch absorption

18

Side effect of Acarbose?

flatulence, abdo pain

19

What is sitagliptin? what do the 'gliptins' do?

DPP-4 inhibitors, prevent break down of native GLP-1 to increase insulin and decrease glucagon

20

Exnatide is what kind of drug?

GLP-1 receptor agonist S.C. injection

21

What are sodium glucose cotransporter 2 SGLT2 inhibitors for?

drugs that slow renal glucose reabsorption

22

DMII treatment flow chart?

Dx > lifestyle > monotherapy > combo therapy > combotherapy with insulin