Biochemistry- Clinical and General Flashcards Preview

NPLEX I > Biochemistry- Clinical and General > Flashcards

Flashcards in Biochemistry- Clinical and General Deck (30)
1

What are 3 sources of glucose in the body?

gluconeogenesis, dietary, glycogen breakdown

2

How is glucose transported in the body?

freely in the blood

3

Glycogen is formed in all tissues, but especially in which 3?

liver, cardiac and skeletal muscle

4

Complete oxidation means what?

The complete breakdown of carbohydrates, proteins or fatty acids into ATP, Co2 and H2O

5

Incomplete oxidation or anaerobic glycolysis forms what substance?

lactate

6

Excess glucose is converted into what?

fatty acids, especially in adipose and liver tissue

7

what are two sources of triglycerides?

diet
synthesis by liver and mucosal cells of the intestine

8

How are dietary triglycerides transported?

chylomicrons

9

How do triglycerides travel from the liver into the blood?

VLDL

10

T/F: triglycerides can cross membranes

False, they need lipoprotein to cross membranes

11

What kinds of bonds does lipoprotein lipase break?

Ester bonds

12

What is the fate of triglycerides?

Get broken down by lipoprotein lipase and FFAs are released

13

How are FFAs transported?

with albumin in the blood

14

What are 2 sources of blood cholesterol?

Diet and liver synthesis

15

Glucokinase, hexokinase, phosphofructokinase and pyruvate kinase are found in which biochemical pathway?

glycolysis

16

Which enzyme, when activated, allows acetyl-CoA to be used for gluconeogenesis?

Pyruvate carboxylase

17

Which enzyme, when activated, allows acetyl-CoA to be used for ATP production?

Pyruvate dehydrogenase complex

18

Glucose-6-phosphate, fructose 1,6-diphosphate, pyruvate carboxykinase are found in what pathway?

gluconeogenesis

19

Carnitine is found in which pathway?

Lipolysis/ Beta oxidation

20

Palitoyl-CoA is found in which pathway?

Lipogenesis

21

malonyl-CoA is found in which pathway?

Lipogenesis

22

Acetyl-CoA carboxylase is found in which pathway?

Lipogenesis

23

Ubiquinone and cytochromes are found in which pathway?

electron transport chain

24

Citrate lyase is found in which pathway?

lipogenesis

25

Delta-6 desaturase is found in which pathway?

Eicosanoid production (Series 1, 3)

26

Phospholipase A2 is found in which pathway?

eicosanoid production from arachadonic acid (releases AA from membranes)

27

Cyclooxygenase is found in which pathway?

prostaglandin and thromboxane 2 synthesis

28

HMG-CoA reductase is found in which pathway?

cholesterol synthesis

29

7-alpha hydroxylase is found in which pathway?

bile synthesis

30

Mevalonate is found in which pathway?

cholesterol or CoQ10 synthesis