Canine Pharmaceuticals

Question 1

Where should fresh semen be deposited in the dog?

Answer 1

Cranial vagina

Question 2

What is a progestin that is approved for used in breeding bitches?

Answer 2

Ovaban (megestrol acetate)

Question 3

What species can Ovaban (megestrol acetate) not be used in?

Why?

Answer 3

• Cats

- Can cause diabetes mellitus

Question 4

What type of dosing is required with Ovaban (megestrol acetate)?

Answer 4

Daily dosing

Question 5

When must Ovaban (megestrol acetate) be started by in order to be effective?

Answer 5

Must be started in first 3 days of proestrus to be effective.

Question 6

When will the next estrous cycle start after the administration of Ovaban (megestrol acetate)?

Answer 6

4-6 weeks earlier

Question 7

Other progesterones can predispose a dog to what 2 conditions?

Answer 7

• Cystic endometrial hyperplasia

- Pyometra

Question 8

Progesterone needs to be in what concentration or lower range to consider supplementing?

Answer 8

3 ng/mL

Question 9

What needs to be known in order to know when to stop supplementing?

Answer 9

When due to whelp

Question 10

What can be used later in pregnancy that allows you to still measure P4 to see if hypoluteoidism is real or not?

Answer 10

Regumate (Altrenogest)

Question 11

If supplementing with progesterone, ideally wait until what day?
Why?

Answer 11

• After 45 days of pregnancy (avoid 1st trimester)

- Avoid masculinization of female pups

Question 12

When should progesterone supplementation be removed?

Why?

Answer 12

• 2-3 days prior to due date

- Allow cervix to relax adequately

Question 13

What is an androgenic compound that prevents LH release by negative feedback, thereby preventing estrus?

Answer 13

Mibolerone

Question 14

Mibolerone is contraindicated in what species?

Why?

Answer 14

• Cats

- Liver toxicity

Question 15

Is Mibolerone approved for use in breeding bitches?

Answer 15

No

Question 16

What type of dosing is required with Mibolerone?

Answer 16

Daily oral dosing

Question 17

When does Mibolerone need to be started?

Answer 17

30 days prior to next anticipated cycle

Question 18

What are 2 side effects that can be seen with the use of Mibolerone?

Answer 18

• Clitoral hypertrophy

- Vaginitis

Question 19

Is Mibolerone recommended for use in breeding bitches?

Answer 19

No

Question 20

When has mibolerone been used in bitches?

Answer 20

Used in bitches with short interestrus intervals

Question 21

Mibolerone can help to achieve an IEI of what length?

Answer 21

At least 5 months

Question 22

Before using mibolerone, make sure the bitch is not what?

Answer 22

Make sure not pregnant with baseline P4

Question 23

What is a long acting implant (6-12 months) that down regulates the pituitary-gonadal axis?

Answer 23

Deslorelin (GnRH analogue)

Question 24

What is a side effect that can be seen with “mismating” shots?

Answer 24

Pyometra

Question 25

What is given in a "mismating" shot?

Answer 25

Estrogen

Question 26

Estrogen toxicity can cause what in dogs and ferrets?

Answer 26

Bone marrow suppression

Question 27

How frequently can an estrogen shot be given?

Answer 27

Not more than once every 30 days

Question 28

What are 3 other options that can be used instead of "mismating" shots?

Answer 28

- Spaying once in diestrus - Waiting until day 28-30 then abort pregnancy - Allow whelping

Question 29

Antiprotestins bind to what? | They have no effect on what?

Answer 29

- Bind to progesterone receptors | - No effect on progesterone

Question 30

Aglepristone is an example of a what? | What can it be used for?

Answer 30

- Antiprogestin | - Early "mismating" shot

Question 31

Multiple small in sections of prostaglandin will do what in the bitch or queen?

Answer 31

Lyse the CL

Question 32

What are 5 possible side effects that can be seen with prostaglandins?

Answer 32

- Drop in blood pressure - Vomiting - Diarrhea - Salivation - Panting

Question 33

What are 3 indications for the use of prostaglandin?

Answer 33

- Pyometra - Retained placenta - Mismating - Collection of males

Question 34

When is the best time to used prostaglandins?

Answer 34

During second trimester

Question 35

What are 2 prolactin inhibitors?

Answer 35

- Bromocriptine | - Cabergoline

Question 36

Which prolactin inhibitor is a dopamine agonist?

Answer 36

Bromocriptine

Question 37

Which prolactin inhibitor is a serotonin antagonist?

Answer 37

Cabergoline

Question 38

Prolactin is luteotropic in the bitch and queen during what trimester?

Answer 38

Second trimester

Question 39

How is prolactin luteotropic?

Answer 39

CL will lyse in response to lowered prolactin levels.