Flashcards in Cardiac Pharm - Stuff Tom Can't Remember Deck (31):
Blurry yellow vision
List drug classes indicated in use in Primary (Essential) HTN
Angiotensin II Receptor Blockers
Dihydropyridine Ca2+ channel blockers (nifedipine)
What is Beck's Triad? What do these symptoms indicate?
2. Increased JVP (distended neck veins)
3. Distant, muffled heart sounds
Indicates acute cardiac tamponade!
What is Kussmaul's sign? What does it indicate?
Increase in JVP on inspiration instead of a normal decrease.
Seen in constrictive pericarditis, restrictive cardiomyopathies, RA or RA tumors.
What is pulsus paradoxus? What does that indicate?
Decrease in systolic BP by >10mmHg during inspiration.
Indicates cardiac tamponade, asthma, obstructive sleep apnea, pericarditis.
How are each of the three types of hyponatremia treated?
Hypovolemic hyponatremia -- saline injection
Euvolemic and Hypervolemic hyponatremia -- Vaptams may be used (ADH receptor antagonists)
What valvular defect presents with a holosystolic murmur?
Mitral regurgitation (intensity of murmur constant through systole)
What valvular defect presents with a midsystolic murmur (crescendo-decrescendo)?
What valvular defect presents with a blowing diastolic murmur?
What valvular defect presents with a holosystolic machine like murmur?
What is the general MOA for fibrates?
Activate PPAR-alpha to induce HDL synthesis.
Activate LPL to clear more triglycerides from the blood.
List all of the Class I Anti Arrhythmics we discussed
What kinds of arrhythmias are indicated for Class IA anti-arrhythmics?
Atrial and ventricular arrhythmias
What kinds of arrhythmias are indicated for Class IB anti-arrhythmics?
Lidocaine is used for arrhythmias post MI
Ventricular tachycardia and fibrillation
What kinds of arrhythmias are indicated for Class IC anti-arrhythmics?
Supraventricular arrhythmias in otherwise normal hearts
What kinds of arrhythmias are indicated for Class II anti-arrhythmics?
Preventing recurrent infarction and sudden death after MI
Exercise induced arrhythmias
AV node reentry
What kinds of arrhythmias are indicated for Class III anti-arrhythmics?
Recurrent ventricular tachycardia or fibrillation
DOC for out of hospital Cardiac arrest
Dronedarone currently used for atrial fibrillation/flutter
What kinds of arrhythmias are indicated for Verapamil?
Reentry arrhythmias involving the AV node
Slowing ventricular rate in atrial fibrillation/flutter
What is the indication for adenosine?
Converting paraoxysmal supraventricular tachycardia to sinus rhythm
What drugs might you use to convert A fib or paraoxysmal supraventricular tachycardia to sinus rhythm?
What drugs might you use to maintain sinus rhythm in A fib or paraoxysmal supraventricular tachycardia?
What drugs might you use for ventricular rate control in A fib or paraoxysmal supraventricular tachycardia?
Diltiazem or Verapamil
Propranalol or Esmolol
What would you use to treat ventricular tachycardia in a patient without heart disease?
What are the indications of spironolactone?
Primary or secondary hyperaldosteronism
Cirrhosis of the liver
Could be used with K+ wasting diuretics to prevent hypokalemia
Oral anti-IIa (thrombin) agent
Oral anti-Xa agents
IV Anti-IIa (thrombin) agents
B2 (bradykinin) receptor antagonist
Used for angio-neurotic edema
What is Dressler Syndrome?
Autoimmune pericarditis that occurs weeks to months after an MI
What are some big lab manifestations of DIC?
Shistocytes and fragmented RBCs on peripheral smear
Prolonged PT and APTT
Decreased fibrinogen level