Serotonergic Drugs

Question 1

Buspirone?

Answer 1

5HT1A agonist. Treats generalized anxiety disorder. May be used off label in conjunction with SSRI for major depression.

Question 2

Sumatriptan?

Answer 2

5HT1D agonist. Used to treat migraines. The drug causes cerebral vasoconstriction and decrease inflammatory response to help end migraines.

Question 3

Fluoxetine?

Answer 3

SSRI. Used to treat depression, OCD, or PTSD. Increases amount of 5HT at the synapse.

Question 4

Sertraline?

Answer 4

SSRI (selective serotonin reuptake inhibitor). Used to treat depression, OCD, or PTSD. Increases amount of 5HT at the synapse.

Question 5

Trazadone?

Answer 5

SARI (Serotonin antagonist and reuptake inhibitor). Blocks 5HT2A/2C receptors to treat depression and anxiety while avoiding the negative side effects of SSRIs.

Question 6

Risperidone?

Answer 6

5HT2A/2C + D2/3 antagonist. Used in the treatment of schizophrenia with psychosis. Decreases activation of the mesolimbic pathway.

Question 7

Odansetron?

Answer 7

5HT3 receptor antagonist. Used in patients with chemotherapy-induced emesis.

Question 8

Mosapride and Cisapride?

Answer 8

5HT4 receptor agonists not currently allowed for use in the US. Increase gut motility related to gastroparesis (slowing of gut motility).