Oxazolidinones Flashcards Preview

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Flashcards in Oxazolidinones Deck (10):
1

What are the two oxazolidinones?

Linezolid
Tedizolid

2

Linezolid Mechanism of Action

Static or Cidal?

Binds the 50S subunit of bacterial ribosomes, preventing formation of the 70S ribosome when combining with the 30S subunit

BACTERIOSTATIC

3

Linezolid Mechanisms of Resistance

Alterations in ribosomal binding sites (rare)

4

Linezolid Spectrum of Activity

Gram Positives
MSSA, MRSA, coagulase negative Staph
Strep pneumoniae, PRSP
Enterococcus (including VRE)

NOT ACTIVE against C diff

5

Linezolid Absorption

IV or Oral
100% bioavailability
CSF Penetration is about 30%

6

Linezolid Elimination

Has Renal and nonrenal elimination

DO NOT need to adjust dosing for renal insufficiency

7

Linezolid Clinical Uses

Serious/complicated infections caused by resistant Gram Positive bacteria
-VRE bacteremia
-Nosocomial pneumonia due to MRSA
-serious infections due to MRSA
-Use Linezolid when you cannot use vancomycin

8

Linezolid Drug Interactions

DO NOT use linezolid with SSRIs or MAOIs. Could cause serotonin syndrome.

Could enhance pressor response to dopamine or epinephrine

9

Linezolid Adverse Effects

Lactic acidosis
Peripheral Neuropathy
Thrombocytopenia
Anemia

10

What is the advantage for using tedizolid over linezolid?

No SSRI interactions!

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