Lipopeptides

Question 1

What is the lipopeptide we talked about?

Answer 1

Daptomycin

Question 2

Daptomycin Mechanism of Action

Answer 2

Binds bacterial membranes and causes depolarization of membrane potential

Inhibits DNA, RNA, and protein synthesis

Question 3

Daptomycin exhibits ___ dependent ____ activity.

Answer 3

Concentration dependent bactericidal activity

Question 4

Daptomycin Spectrum of Activity

Answer 4

Gram Positives only
MSSA, MRSA, VRSA
PRSP
VRE

Question 5

Daptomycin Absorption and Distribution

Answer 5

Only given by IV

Rapidly distributes to well perfused tissues

Question 6

Daptomycin Elimination

Answer 6

Primarily excreted renally.

Adjust dose for renal insufficiency

Question 7

Daptomycin Clinical Uses (and when not to use)

Answer 7

Used for serious/complicated infections by resistant bacteria

Should NOT be used in pneumonia

Question 8

Daptomycin Adverse Effects

Answer 8

Myopathy and CPK Elevation in small %
GI - nausea/diarrhea
HA
Rash

Question 9

Daptomycin Drug Interactions

Answer 9

Interact with HMG-CoA reductase inhibitors to cause increased risk of myopathy

Question 10

Quinipristin-Dalfopristin

Answer 10

Have a synergistic effect as protein synthesis inhibitors for Gram Positive organisms