Flashcards in Ch.20: Antimicrobial Drugs Deck (10):
Act by killing or by interfering with the growth of microorganisms. Must often act within the host without damaging the host. SELECTIVE TOXICITY
a substance produced by microorganisms that in small amounts inhibit other microorganisms
Some drugs have a _____ ______ __ _______ ______, or range of different microbial types that they affect.
narrow spectrum of microbial activity
A primary factor involved in the selective toxicity of antibacterial actions lies in the
lipopolysacchride outer layer of gram negative bacteria, peptidoglycan and the porins
Five modes of action of antimicrobial drugs inlcude
inhibiting cell wall synthesis
inhibiting protein synthesis
injuring the plasma membrane
inhibiting nucleic acid synthesis
inhibiting the synthesis of essential metabolites
True Or False: Antimicrobial drugs usually must target microbial structures or function that ARE shared with mammalian structures or functions.
FALSE: THEY TARGET ONES THAT ARE NOT SHARED.
Antibacterial Drugs Targets:
peptidoglycan of the cell wall
Antifungal Drugs Target:
ergosterols in the plasma membrane
cell wall CHITIN (glucan)
Antiprotozoan Drugs Targets:
target specific characteristics for the different types of protozoa. MORE TOXIC