Ch.20: Antimicrobial Drugs Flashcards Preview

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Flashcards in Ch.20: Antimicrobial Drugs Deck (10):
1

Act by killing or by interfering with the growth of microorganisms. Must often act within the host without damaging the host. SELECTIVE TOXICITY

antimicrobial drugs

2

a substance produced by microorganisms that in small amounts inhibit other microorganisms

antibiotic

3

Some drugs have a _____ ______ __ _______ ______, or range of different microbial types that they affect.

narrow spectrum of microbial activity

4

A primary factor involved in the selective toxicity of antibacterial actions lies in the

lipopolysacchride outer layer of gram negative bacteria, peptidoglycan and the porins

5

Five modes of action of antimicrobial drugs inlcude

inhibiting cell wall synthesis
inhibiting protein synthesis
injuring the plasma membrane
inhibiting nucleic acid synthesis
inhibiting the synthesis of essential metabolites

6

True Or False: Antimicrobial drugs usually must target microbial structures or function that ARE shared with mammalian structures or functions.

FALSE: THEY TARGET ONES THAT ARE NOT SHARED.

7

Antibacterial Drugs Targets:

peptidoglycan of the cell wall
70s ribosomes
plasma membrane

8

Antifungal Drugs Target:

ergosterols in the plasma membrane
cell wall CHITIN (glucan)

9

Antiprotozoan Drugs Targets:

target specific characteristics for the different types of protozoa. MORE TOXIC

10

Antihelminthic Drugs Target:

Inhibition of ATP production
Alters permeability of the plasma membrane