Chapter 13 :: Basic Principles of Immunologic Diseases in Skin (Pathophysiology of Immunologic/Inflammatory Skin Diseases)

Question 1

• Cytokine, Toll-like receptor and inflammasome-mediated activation of APCs
• No skin inflammation
  Initial hapten exposure

Answer 1

Sensitization (Allergic contact dermatitis)

Question 2

Cytokine, Toll-like receptor and in inflammasome-mediated activation of APCs
* Skin inflammation elicited by T cells
Subsequent exposure

Answer 2

Elicitation (Allergic contact dermatitis)

Question 3

• Resident memory T cells poised for subsequent exposure
  Postinflammation

Answer 3

Resolution (Allergic contact dermatitis)

Question 4

Existence of clones of drug-reactive CD8+ resident memory T (TRM) cells that remain at sites of previous skin lesions where they are poised to respond if offending drugs are readministered

Answer 4

Fixed Drug Erupions : resident memory T cells

Question 5

A disease with eczematous dermatitis as a prominent feature, is caused by mutations in the cell surface protease inhibitor SPINK5

Answer 5

Netherton syndrome

Question 6

Loss of SPINK5 leads to increased activity of cell surface serine proteases that compromises the barrier function of the stratum corneum

Question 7

Blocks IL-4 and IL-13 signaling

Answer 7

Dupilumab

Question 8

Expressed in oral and esophageal mucosae, mucosal involvement is observed in PV but not in PF

Answer 8

Dsg3

Question 9

Binds the cell surface protein CD20 that is expressed by B cells

Answer 9

Rituximab