Chapter 78 :: Acne Vulgaris Flashcards
four key elements of pathogenesis of acne
(1) follicular epidermal hyperproliferation, (2) sebum production, (3) the presence and activity of Propionibacterium acnes, and (4) inflammation and immune response.
most sensitive test for PCOS
free testosterone
considered safe in pregnancy
Azelaic Acid
inhibits the formation of free fatty acids and has presumptive keratolytic properties
inhibition of para-aminobenzoic acid (PABA), an essential substance for P. acnes growth
Sulfur
dosages of 50–100 mg twice a day
Spironolactone
management of treatment-resistant acne
isotretinoin
Laboratory monitoring while patients are taking isotretinoin with the greatest attention paid to
serum triglyceride levels
recommended daily dosage of isotretinoin
0.5 to 1 mg/kg/day
Low-dose regimens, 0.1 to 0.4 mg/kg/day
incidence of relapses after therapy is greater
