Chapter 61 :: Lupus Erythematosus

Question 1

SLE Criteria

Answer 1

1. Malar rash
2. Discoid rash
3. Photosensitivity
4. Oral ulcers
5. Arthritis
6. Serositis
7. Renal disorder
8. Neurologic disorder
9. Hematologic disorder
10. Immunologic disorder

11.

Antinuclear antibody

Question 2

most upregulated gene pathway identified in microarray studies in SLE patients

Answer 2

type 1 IFN

Question 3

Although perivascular nail fold erythema and telangiectasia can occur, they are considerably more common and occur in more exaggerated forms in dermatomyositis and systemic sclerosis

Answer 3

ACUTE CUTANEOUS LUPUS ERYTHEMATOSUS

Question 4

typically precipitated or exacerbated by exposure to UV light.
This form of CLE can be quite ephemeral, lasting only hours, days, or weeks

Answer 4

ACLE

Question 5

initially presents as erythematous macules and/or papules that evolve into hyperkeratotic papulosquamous or annular/polycyclic plaques

Answer 5

SCLE

Question 6

SCLE lesions tend to be less transient than ACLE lesions and heal with more pigmentary change. They are also less edematous and more hyperkeratotic than ACLE lesions

Question 7

most common form of CCLE

Answer 7

Classic DLE

Question 8

nonscarring alopecia that patients with SLE often develop during periods of systemic disease activity

Answer 8

lupus hair

Question 9

hyperkeratosis, epidermal atrophy, vacuolar basal cell degeneration, dermal–epidermal junction basement membrane thickening, dermal edema, dermal mucin deposition, and mononuclear cell infiltration of the dermal–epidermal junction and dermis, focused in a perivascular and periappendageal distribution.

Answer 9

LE specific histopathology