Cholesterol Flashcards Preview

Cmbm 2 Gopi > Cholesterol > Flashcards

Flashcards in Cholesterol Deck (7)
Loading flashcards...
0

what is the rate limiting step in cholesterol biosynthesis?

HMG-CoA reductase

many drugs developed to attack this enzyme

1

how is cholesterol transported?

transported as VLDL

2

What catalyzes the esterification of cholesterol?

Acyl CoA cholesterol Acyl Transferase (ACAT)

3

Cholesterol is precursor for steroid hormones

examples
Glucocorticoids
Mineralcorticoids
Androgens
Estrogens
Progestins

4

Gall stones

if CH crystalizes due to increased CH:phospholipid ratio

5

Atherosclerosis

Foam cells form from Macrophages that have been attracted due to inflammation from constant oxidation of cholesterol in the arterial intima

6

Statins inhibit

HMG-CoA reductase