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Flashcards in T cell differentiation, subsets, receptors Deck (74)
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T and B cell lymphocytes begin to express antigen receptors ...

as precursor cells in the primary lymphoid tissue following random recombination of genes

1

if mature t cell expresses 10 million TCR molecules on its plasma membrane, how many antigen specificities would the cell express?

1

2

where are gamma-delta T cells found?

found as intraepithelial lymphocytes

3

What cytokines do Th1 cell produce?

Y-IFN

4

what cytokines do Th2 cells produce?

IL4, IL5, IL13

5

what cytokines do Th17 cells produce?

IL 17
IL 22

6

Where do Naive T cells encounter antigen?

In the paracortex of lymph nodes or the PALS of the spleen

when APCs and T cell travel to the lymph nodes this optimizes the interaction of antigen presentation

7

What happens upon Naive CD4 T cell activation?

after antigen presentation, there is clonal expansion and differentiation to either Th1, Th2 or Th17 cells

8

What type of infection do Th1 cells aid in?

intracellular
and aid in inflammtion

9

what type of infection doe Th2 cells aid in?

Parasitic - Helmiths
Allergic reactions

10

what type of infections do Th17 cells aid in?

Some bacteria and fungi
inflammatory disorders
extracellular pathogens
bring in additional neutrophils

11

what is the main leukocyte that Th1 cells recruit?

monocytes

12

what is the main leukocyte recruited by Th2 cells?

Eosinophils

13

what is the main leukocyte recruited by Th17 cells?

Neutrophils
monocytes

14

what kind of antibody isotypes are stimulated by Th1 cells?

complement
Fc receptor binding IgG subclasses

15

What types of antibody isotypes does Th2 stimulate?

IgE
IgG4

16

Naive CD4 T cells interact with antigen

presented on MHC II molecules by APCs in the secondary lymphoid tissue

17

List the steps of T cell activation

Antigen recognition
Activation
Clonal expansion
Differentiation - during differentiation get effector and memory
Effector functions

18

Effector CD4 T cells

activate macrophages and B cells

19

Effector CD8 T cell

Kill infected target cells
activate macrophages

20

where are T cells activated?

paracortex of lymph nodes
or PALS of spleen

21

what molecules are required for T cell activation?

APC - MHC2, CD80/86 (B7)
T cell - CD3, CD4, CD28, TCR

22

what are the three signals required for T cell activation? CD4 or CD8

signal 1 - interaction with MHC - adhesion molecules stabilize interaction.

signal 2 - co stimulation

signal 3 - cytokines from APC

23

In cell to cell interactions of activation of Cd4 cells, what molecules play a role in adhesion?

LFA-1 on CD4 T cells
ICAM-1 on the APC

24

What is absolutely required activation?

costimulation

25

CTLA4 interacts with

B7

26

when is IL 2 produced?

after antigen presentation but before proliferation
promotes T cell proliferation
positive feedback to the cell producing it

27

Naive CD4 T cell secretes IFN-y and IL-12 to induce

Th1 cells

28

Naive CD4 T cells release IL-4 to induce

Th2 cells

29

Naive CD4 T cells secrete TGF-b, IL-6 and IL-23 to induce

Th17 cells