Flashcards in T cell differentiation, subsets, receptors Deck (74)
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T and B cell lymphocytes begin to express antigen receptors ...
as precursor cells in the primary lymphoid tissue following random recombination of genes
1
if mature t cell expresses 10 million TCR molecules on its plasma membrane, how many antigen specificities would the cell express?
1
2
where are gamma-delta T cells found?
found as intraepithelial lymphocytes
3
What cytokines do Th1 cell produce?
Y-IFN
4
what cytokines do Th2 cells produce?
IL4, IL5, IL13
5
what cytokines do Th17 cells produce?
IL 17
IL 22
6
Where do Naive T cells encounter antigen?
In the paracortex of lymph nodes or the PALS of the spleen
when APCs and T cell travel to the lymph nodes this optimizes the interaction of antigen presentation
7
What happens upon Naive CD4 T cell activation?
after antigen presentation, there is clonal expansion and differentiation to either Th1, Th2 or Th17 cells
8
What type of infection do Th1 cells aid in?
intracellular
and aid in inflammtion
9
what type of infection doe Th2 cells aid in?
Parasitic - Helmiths
Allergic reactions
10
what type of infections do Th17 cells aid in?
Some bacteria and fungi
inflammatory disorders
extracellular pathogens
bring in additional neutrophils
11
what is the main leukocyte that Th1 cells recruit?
monocytes
12
what is the main leukocyte recruited by Th2 cells?
Eosinophils
13
what is the main leukocyte recruited by Th17 cells?
Neutrophils
monocytes
14
what kind of antibody isotypes are stimulated by Th1 cells?
complement
Fc receptor binding IgG subclasses
15
What types of antibody isotypes does Th2 stimulate?
IgE
IgG4
16
Naive CD4 T cells interact with antigen
presented on MHC II molecules by APCs in the secondary lymphoid tissue
17
List the steps of T cell activation
Antigen recognition
Activation
Clonal expansion
Differentiation - during differentiation get effector and memory
Effector functions
18
Effector CD4 T cells
activate macrophages and B cells
19
Effector CD8 T cell
Kill infected target cells
activate macrophages
20
where are T cells activated?
paracortex of lymph nodes
or PALS of spleen
21
what molecules are required for T cell activation?
APC - MHC2, CD80/86 (B7)
T cell - CD3, CD4, CD28, TCR
22
what are the three signals required for T cell activation? CD4 or CD8
signal 1 - interaction with MHC - adhesion molecules stabilize interaction.
signal 2 - co stimulation
signal 3 - cytokines from APC
23
In cell to cell interactions of activation of Cd4 cells, what molecules play a role in adhesion?
LFA-1 on CD4 T cells
ICAM-1 on the APC
24
What is absolutely required activation?
costimulation
25
CTLA4 interacts with
B7
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when is IL 2 produced?
after antigen presentation but before proliferation
promotes T cell proliferation
positive feedback to the cell producing it
27
Naive CD4 T cell secretes IFN-y and IL-12 to induce
Th1 cells
28
Naive CD4 T cells release IL-4 to induce
Th2 cells
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