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Flashcards in Dermatopathology Deck (126)
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1

Acantholysis

Loss of keratin cohesiveness

2

Acanthosis

Increased thickness of stratum spinosum

3

Alopecia

Hair loss/ failure to grow

4

Atopy

Allergic skin disease

5

Ballooning degeneration

Intracellular oedema

6

Bullae

Collection of fluid > 1cm in diameter

7

Folliculitis

Luminal, mural or perifollicular inflammation of the hair follicle

8

Furunculosis

Luminal, mural or perifollicular inflammation secondary to rupture of the follicular wall (keratin = non-self)

9

Dermal pyogranulomatous inflammation

Furunculosis

10

Hyperkeratosis

Increased keratin thickness (may be para/ orthrokeratotic nuclei)

11

Parakeratotic

Nuclei seen

12

Orthokeratotic

No nuclei seen

13

Pustule

Cavitation of epidermis filled with inflammatory cells

14

Pigmentary incontinence

Melanin/ melanophages within the dermis

15

Seborrhoea

Increased scale with or without greasiness

16

Seborrhoea olesa

Increased scale with increased greasiness

17

Seborrhoea sicca

Increased scale without greasiness

18

Spongiosis

Epidermal intercellular oedema

19

Vesicle

Fluid filled blister

20

Name three aetiological agent which cause vasculitis

Rickettsia

Autoimmunity - immune complexes

Erysipelothrix - septic emboli

21

Purpura

Purple-red rash of the skin

22

Vasculitis is characterised by what gross changes?

Erythema

Plaques

Macules

Purpura

Ulceration

Dermal atrophy with chronicity

23

Describe this lesion

The skin of this pig shows multifocal to coelescing 'diamond-shaped' erythrematous red lesions. They range in size from 3x3 cm to 1x1cm. They are dark red at the periphery but often have a pale centre.

Acute severe multifocal-coelescing erythrematous vasculitis

Diamond disease - Erysipelothrix

24

What pathological change is seen on this histological slide?

Adnexal atrophy - fading follicles, characteristic of chronic vasculitis

25

What type of vasculitis is characterised in this image?

What aetiology would be expected?

Neutrophilic 

Due to type 3 hypersensitivity or septicaemia

26

What type of vasculitis is characterised in this image?

What aetiology would be expected?

Lymphoplasmacytic

Cell-mediated

27

What type of vasculitis is characterised in this image?

What aetiology would be expected?

Eosinophilic

Type 1 hypersensitivity

28

What histological changes would be expected with vasculitis?

Karyorrhectic cell debris

Fibrinoid necrosis + fibrin/ haemorrhage

Faded follicles with chronicity

29

Describe the lesion.

Multifocal to coelescing redenning of the skin. Round lesions show flaking scale at the edges and range from 1x1cm to 3x3cm. Erythrematous papules.

Histologically: subcorneal pustules and n# infiltration

Acute moderate to severe multifocal to coelescing haemorrhagic dermatitis

Aetiology: Pemphigus foliaceus

30

Describe this lesion

The skin of this piglet shows extensive focal erythema. Large grey to brown crusts are present. Approximately 20% of the skin of the face is affected.

Acute severe focally extensive bacterial dermatitis.

Aetiology: Staphylococcus hyicus exotoxin (MMP)