Which area of the pancreas is usually affected by juvenile a/hypoplasia?
Exocrin - islets are unaffected
Leads to fatty faeces, poor condition despite good appetite
Differentials for pancreatic haemorrhage
- Infectious - CAV1 - canine infectious hepatitis
- Intoxication- dicumarol
Viral infections leading to pancreatitis.
Canine infectious hepatitis - CAV1
Acute diffuse severe necrotising pancreatitis coupled with adjacent fat necrosis.
Due to release and activation of pancreatic enzymes WITHIN the pancreas
Leads to acute death - DIC or Chronic fibrosing pancreatitis (EPI and DM)
Chronic fibrosing pancreatitis - leads to nodular, undulating surface of pancreas
Histologically: fibroblasts are seen amongst streams of collagen fibres which distrupt the normal ascini formation - no islets can be seen
Clinical loss of 80% or more of the functional exocrine pancreas
- Juvenile atrophy
- Chronic pancreatitis
- Exocrine pancreatic neoplasia
Outcomes of EPI.
Malabsorption of vitamins
DM - if secondary to chronic pancreatitis
Nodular hyperplasia of the pancreas
Degenerative change, non-encapsulated, non-infiltrative nodules seen in old animals
No contraction between nodules (x fibrosis), distinct lesions
Which cells of the pancreas do adenocarcinomas arise from?
Ascini or ducts
This very aggresive pancreatic tumour is capable of local duondenal invasion, haematogenous spread, implatation and lymphogenic spread.
Primary diabetes mellitus is caused by what?
- Pancreatitis - acute and chronic
- Islet hypoplasia - early-onset
- Islet amyloidosis
- Chronic infection - FMD, BVD