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Flashcards in development of the genital system Deck (61):
1

when does the determination of sex occur ?

at fertilizations (determined by male gamete)

2

if the germ cells fail to reach the genital ridges

gonads do not

3

What forms the primitive sex cords ?

coelomic epithelium proliferates and penetrates the mesenchyme to form primitive sex cords

4

3 contributions to the gonads ?

germ cells (endoderm)
coelomic epithelium
mesenchymal cells (Ct)

5

development of the testes is induced by what gene

sry

6

what does the the sry gene encode

Testis dermining factor (TDF)

7

What does TDF cause

sex cords proliferate to form testis
cords grow into a network that will give rise to rete testes
tunica albuginea seperates cords from surface epithlieum

8

seminiferous cords form

seminiferous tubules (sertoli cells and spermatogonia) straight tubules, rete tests and mesenchymal cells

9

what do mesenchymal cells form

leydig cells that produce testerone in week 8

10

which gonad develops first

right

11

descent of the testes is associated with

enlargement of the testes
atrophy of the mesonephric kidney
atrophy of the paramesonephric ducts
enlargement of the processus vaginalis

12

the gubernaculum attached to the uterus becomes what

ovarian ligament and round ligament of uterus

13

canal of nuck

persistent processus vaginalis in female

14

mesonephric duct

duct of the intermediate kidney

15

paramesonephric duct

a longitudinal derivative of epithleium of the urogenital ridge; cranially the duct opens into the coelomic cavity; caudally the two ducts join and fuse together

16

the development of the genital ducts is controlled by

TDF

17

mullerian inhibiting factor

produced by sertoli cells and inhibit development of the mullerian duct

18

testosterone

produced by leydig cells and stimulate continued development of the mullerian duct

19

the mesoneprhic duct gives rise to

epididymis, ductus deferens, ejaculatory duct and seminal vesicle

20

in males the _________ regresses and the ________ perisists

mullerian, mesonephric

21

what are the remnants of mullerian ducts

appendix of testi (paradidymuss) and protatic utricle

22

paramesonephric duct gives rise to what in females

uterine tube, uterus and superior part of vagina

23

remnants of the mesonephric ducts in females

epoophoron+ paraoophoron and the gartner's cyst

24

gartner's syst

scattering of tiny remnants of the mesonephric duct that remain near the vagina

25

the vaginal epithlium arises from

endoderm of the UG sinus,

26

the fibromuscular wall of the vagina arises from

surrounding mesenchyme

27

sinovaginal bulbes fuse to form

vaginal plate (hymen)

28

upper portion of vagina derived from

paramesonephric ducts

29

lower portion of the vagina derived from

urogenital sinus

30

the indifferent gonad becomes what in females and males

testes in males and ovary in females

31

the gubernaculum becomes what in f and m

gubernaculum testes
ovarian ligament and round ligament of uterus

32

genital tubercle becomes what in males and females

males-penis
females-clitoris

33

urogenital folds become what in males and females

labia mainora in females and penis in males

34

genital swellings become what in males and females

scrotum
labia majora

35

phenotypic sex is determined over a long period of time during development and depends on

MIF, testosterone, dihydrotestosterone, and critical timing

36

turner syndrome

45 X0, germ cells degenerate after reaching gonadal ridge; ovaries do NOT form but rather ovarian streaks form

37

migration of germ cells during week 2

arise from the epiblast

38

week 3 migration of germ cells

yolk sac

39

week 5 migration of germ cells

migration through dorsal mesentery of the hindgut

40

week 6 migration of germ cells

arrive at the genital ridge

41

what does the seminiferous tubules form

sertoli cells and spermatogonia

42

what do the mesenchymal cells from

leydig cells that produce testosterone in week 8

43

INFANnital tubercle becomes what in females

clitoris

44

genitcal tubercle becomes what in males

penis

45

the urethrla groove becomes what in males

penile urethral

46

urthral groove becomes wat in females

vestibule

47

urogenital sinus becomes what in males

bladder, urethra, and prostate

48

urogenical sinus becomes what in females

bladder urethra, portions of the vagina and vestibular glands

49

what are the four stages of development of the reproductive system

development of the sexually indifferent goand, development of the ovary/testis, development of genital ducts, development of external genitalia

50

what week does reproductive development start

week 5

51

gonads are derived from

intermediate mesoderm, mesenchyme, and primordial germ cells

52

when do the primordial germ cells invade the gonadal ridges

week 6

53

uterus didelphys

double uterus with double vagina

54

uternus bicornis

two uteri,one vagina

55

weeks 9-12

external genitalia

56

klinefelter syndrome

47xxy male, but small testes, tall intellegence affected

57

androgen insensitivyt syndrome

46 XY but appear as normal females, resissteance to testosterone defect in androgen receptor

58

hydrocele

processus vginalis doesn't close and accumulates fluid, usually spontaneously closes in a few days

59

cryptoorchidism

undescended testes

60

hypospadias

external urethral opening on ventral side

61

epispadias

external urethral opening on dorsal aspect of penis