Devo Lect 16 - Circulation Flashcards Preview

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Flashcards in Devo Lect 16 - Circulation Deck (12):
2

Vasculogenesis

Initial formation of blood vessels; basically need formation of tubes, heart pumping, and connections to the heart

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Differentiation in Vasculogenesis

Mesoderm cell; FGF2 makes it into hemagioblast; lineages split: angioblast becomes endothelial cell for vessels (VEGF), pluripotent hematopoietic stem cell

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VEGF

Vascular endothelial growth factor; main GF in formation of blood vessels

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Steps in vasculogenesis

Yolk sac endoderm forms tube, blood islands form (hemangioblasts), endothelial cells and blood stem cells differentiate ?????

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Angiogenesis

Formation of blood vessels from pre-existing one; sprouting caused by VEGF; connections finished with other GF

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Understanding of blood vessel formation

cancer studies from Dr. Judah Folkmann; put piece of tumor in rabbit cornea which caused angiogenesis there; purified VEGF after 10 years

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Tumor-induced angiogenesis

Factors like FGF2, VEGF; tumors grow way faster with blood vessels (more nutrients, and wastes removed); also allow cells to metastasize because connections in vessels are loose

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Anti-angiogenesis factors

Angiostatin, endostatin, avastin (Ab to VEGF); most of body not undergoing angiogenesis (except uterus)

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Avastin

Antibody to VEGF; minimizes metastasis and increases survivorship

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Thalidomide

causes focalmelia in infant because it blocks angiogenesis; needs to be metabolized

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Gene therapy for VEGF

Dominant negative receptors, or therapeutic protein via adenovirus

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Problems with gene therapy for VEGF

Problems with wound healing, leaky blood vessels prone to hemorrhage