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Flashcards in Diabetes drugs Deck (15):
1

what must you have if you are to take sulphonylureas?

functioning beta cells

2

name some sulphonylureas?

tolbutamide
gliclazide
glibenclamide
chloropropanide

3

how do sulphonylureas work?

depolarize beta cells, stimulating release of insulin

4

what type of drug suppresses the appetite?

Biguanides e.g metaformin

5

what type of drug is metaformin?

biguanide

6

why is metaformin good in fat people?

it suppresses appetite

7

what is the most serious side effect of metaformin?

lactic acidosis

8

name other side effects of metaformin

nausea
diarrhoea
metallic taste in mouth

9

when should metformin be avoided

renal failure
alcohlism
cirrhossis
chronic lung disease
heart failure
mitochondrial myopthy
any other serious illnesses

10

how do TZDs work? (Thiazolidinediones)

bind to receptors in cell nucleus and affect gene expression, decreasing insulin resistsance

11

name the TZD licensed in the UK?

Pioglitazone

12

how to GLP-1 analogues work?

they mimic the action of GLP 1 (glucogon like peptide) and are thought to

increase insulin secretion
decrease glucagon secretion
increase insulin sensitivity

13

name some GLP-1 analogues?

exenatide and liraglutide

14

what do DDP-4 inhibitors do?

they prevent dipeptyle peptidase -1 (DDP4) inhibiting GLP-1

15

name some DDp-4 inhibitors?

sitagliptin

vildagliptin