Flashcards in Diabetes drugs Deck (15):
what must you have if you are to take sulphonylureas?
functioning beta cells
name some sulphonylureas?
how do sulphonylureas work?
depolarize beta cells, stimulating release of insulin
what type of drug suppresses the appetite?
Biguanides e.g metaformin
what type of drug is metaformin?
why is metaformin good in fat people?
it suppresses appetite
what is the most serious side effect of metaformin?
name other side effects of metaformin
metallic taste in mouth
when should metformin be avoided
chronic lung disease
any other serious illnesses
how do TZDs work? (Thiazolidinediones)
bind to receptors in cell nucleus and affect gene expression, decreasing insulin resistsance
name the TZD licensed in the UK?
how to GLP-1 analogues work?
they mimic the action of GLP 1 (glucogon like peptide) and are thought to
increase insulin secretion
decrease glucagon secretion
increase insulin sensitivity
name some GLP-1 analogues?
exenatide and liraglutide
what do DDP-4 inhibitors do?
they prevent dipeptyle peptidase -1 (DDP4) inhibiting GLP-1