Insulin Secretion and Signalling Flashcards Preview

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Flashcards in Insulin Secretion and Signalling Deck (20):
1

what cells secrete insulin?

B cells (beta)

2

what cells secrete glucagon?

alpha cells

3

what cells secrete somatostatin?

sigma cells

4

what cells secrete pancreatic polypeptide?

PP cells

5

where is insulin made?

in RER of pancreatic B cells

6

how does glucose enter B cells?

via GLUT2 glucose transporter

7

increased metabolism of glucose leads to an increase in what?

intracellular ATP

8

what does ATP inhibit?

the ATP sensitive K+ channels which leads to depolarization of the cell membrane

9

what does depolarization of the cell membrane allow?

the opening of voltage gated Ca++ channels

10

what does an increase in intracellular Ca++ cause?

release of insulin

11

how many proteins make up Katp channels?

2

12

what type of drug directly inhibits Katp channels?

sulphonylurea

13

what is the difference between type 1, type 1 and MODY?

type1- loss of insulin secreting B cells

type 2- reduced insulin sensitivity in tissues

MODY- defective glucose sensing in pancreas and or loss of insulin secretion

14

what does insulin bind to?

insulin receptor

15

which part of the receptor does insulin bind to?

alpha units

16

where are ketone bodies formed?

mitochondria in liver

17

what does excess acetyle co A convert into?

ketone bodies

18

what does the accumulation of ketone bodies cause?

acidosis

19

what exacerbates acidosis?

high glucose excretion -causing dehydration

20

what is ketoacidosic most associated with/

type 1 diabtes