Flashcards in reproductive online modules Deck (27)
what 5 things should you ask about in a gynae history?
oligomenorrhoea and hyperandrogenism are key features of what?
differential for infertility?
pelvic inflammatory disease
premature ovarian failure
most common cause of female infertility?
to be diagnosed with PCOS you must have 2 out of what 3 things?
hyperandrogenism (acne, hairy )
polycystic ovaries on ultrasound
what is menarche
when you start your period
what triggers menarche?
GnRH which is released by hypothalamus
what does an ovarian follicle consist of?
an oocyte surrounded by granulosa cells and theca cells
what do theca cells produce?
androgens (which are then converted to oestrogens by granulosa cells via acromatase enzyme)
when is ovulation day?
what does LH cause theca cells to do?
what does FSH cause granulosa cells to do?
covert androgens to oestrogens
what does too much oestrogen inhibit?
what triggers ovulation
surge in LH
2 phases of menstrual cycle?
what does the remaining follicle turn into in the luteal phase?
what hormone does the corpus luteum release?
what happens to endometrium in the luteal phase?
what does high levels of progesterone do?
inhibit FSH and LH
if no fertilisation what happens to corpus luteum?
degenerate which eventually leads to bleeding (period time!)
why does increase in androgens make you hairy?
because increase in androgens =increase testosterone which gives you more hair (esp on your face)
most appropriate investigation for PCOS?
is PCOS usually unilateral or bilateral?
how can you manage hyperandrogenism?
contraceptive pill alone or in combination with an anit androgen
what can cause premature ovarian failure?
Iatrogenic-surgery, CHEMO, radiation
how can you treaat premature ovarian failure?