Pathology of Pituitary and Adrenal gland Flashcards Preview

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Flashcards in Pathology of Pituitary and Adrenal gland Deck (25):
1

name the trophic hormones secreted from anterior pituitray?

TSH
ACTH
FSH
LH

2

what are the non trophic hormones secreted from the anterior pituitary?

GH
Prolactin

3

what is derived from rathke's pouch?

anterior pituitary

4

name the most common functional pituitary adenoma?

prolactinoma

5

name functional pituitary adenomas?

prolactinoma

GH secreting
ACTH secreting

6

what can cause pituitary hypofunction?

tumours
trauma
surgery/radiation
granulomatous inflammation
infection
haemorrhage
hypothalmic lesions

7

what is craniopharyngioma?

derived from remnants of rathke's pouch
slow growing, cystic, may calcify

headaches, visual disturbance

excellent prognosis

8

what can cause diabetes insipidus?

ADH insufficiency

renal resistance to ADH

9

what are the 3 zones of adrenal cortex?

zona glomerulosa

zona fascicultata

zona reticularis

10

what hormones come from the zona glomerulosa?

mineralacocorticoids
aldosterone

11

what hormones come from zona fasciculata?

glucocorticoids
cortisol

12

what hormones come from zona reticularis?

sex steroids
glucocorticoids

13

what do chromaffin cells in teh adrenal medulla scerete?

catecholamines

14

what can cause hyperfunction of the adrenals?

hyperplasia
adenoma
carcinoma

15

what can cause acute and chronic hypofunction of adrenals?

acute-waterhouse friderichsen

chronic- addisions

16

describe an adrenocortical adenoma?

well circumscribed, encapsulated lesion, usually small

yellow/brown cut surface (lipids)

well differentiated, small nuclei

17

features suggesting adrenocrotical carcinoma?

lareg size
haemorrhage and necrosis
frequent mitoses
lack of clear cells
capsular or vascular invasion

18

what is primary hyperaldosteronism also known as?

conn's syndrome

19

too much cortisol

cushings

20

3 common causes of addisons disease?

autoimmune
infection
metastatic malignancy

21

weakness, fatigue
anorexia/weight loss
nausea
diarrhoea
tanned!
pigmentation

addisons

22

what are the 2 main adrenal medullary tumours?

neuroblastoma

phaechromocytoma (10% tumour)

23

what tumour is also known at the 10% tumour?

phaechromocytoma

24

catecholamines in urine?

phaechromocytoma

25

medullary tumour assocaited with multiple endocrine neoplasia?

phaechromocytoma