Diagnosis of autoimmune diseases (core immunology) Flashcards Preview

Clinical Pathology > Diagnosis of autoimmune diseases (core immunology) > Flashcards

Flashcards in Diagnosis of autoimmune diseases (core immunology) Deck (12):
1

What is the definition of sensitivity and specificity?

SENSITIVITY:
-measure of how good the test is in identifying people with the disease.

SPECIFICITY:
-measure of how good the test is at correctly identifying people without the disease.

2

What is a positive predictive value?

The proportion of people with a positive test who have the target disorder.

3

What is a negative prediction value?

the proportion of people with a negative test who do not have the target disorder

4

Give examples of non specific markers of systemic inflammation?

1) ferretin
2) CRP (C-reactive protein)
3) ESR (erythrocyte sedimentation rate)
4) fibrinogen
5) Haptoglobin
6) Albumin
7) complement

5

What is Rheumatoid factor?

Search Results
Rheumatoid factors are proteins produced by immune system, can attack healthy tissue. High levels of rheumatoid factor in the blood are associated with autoimmune diseases, eg.rheumatoid arthritis.

-usually antibodies (IgM, IgG or IgA)

6

What marker is 95% specific for Rheumatoid arthritis than Rheumatoid factor?

Anti-CCP (ACPA)

ACPA positive patients tend to have more sever and erosive disease,

7

Anti-neutrophilic cytoplasmic antibodies (ANCA) were first described as an autoantibody specific for what disease?

Wegeners granulomatosis

(AKA Granulomatosis with polyangiitis)

Also associated with:
Microscopic polyangiitis and churg-strauss syndrome

8

What ANCA associated systemic vascultidies causes alveoral haemorrhage?

All 3 :
Wegener's granulomatosis
Microscopic polyangiitis
Churg-Strauss syndrome

9

How useful is ANCA testing ?

- a positive ANCA is useful in suggesting the diagnosis
- a negative ANCA does not exclude AASV (ANCA associated systemic vasculitidies)

10

What antibody is specific for primary biliary sclerosis?

Anti-mitochondrial antibody

11

In what disease is anti smooth muscle and anti liver/kidney antibodies found in?

Autoimmune hepatitis

12

What types of autoantibodies are present in type 1 diabetes?

1) Islet cell antibodies
2) Anti-GAD65 and Anti-GAD67
3)insulin autoantibodies (IAAs)
4) Anti-insulinoma antigen

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