Diagnosis of autoimmune diseases (core immunology) Flashcards Preview

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Flashcards in Diagnosis of autoimmune diseases (core immunology) Deck (12):

What is the definition of sensitivity and specificity?

-measure of how good the test is in identifying people with the disease.

-measure of how good the test is at correctly identifying people without the disease.


What is a positive predictive value?

The proportion of people with a positive test who have the target disorder.


What is a negative prediction value?

the proportion of people with a negative test who do not have the target disorder


Give examples of non specific markers of systemic inflammation?

1) ferretin
2) CRP (C-reactive protein)
3) ESR (erythrocyte sedimentation rate)
4) fibrinogen
5) Haptoglobin
6) Albumin
7) complement


What is Rheumatoid factor?

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Rheumatoid factors are proteins produced by immune system, can attack healthy tissue. High levels of rheumatoid factor in the blood are associated with autoimmune diseases, eg.rheumatoid arthritis.

-usually antibodies (IgM, IgG or IgA)


What marker is 95% specific for Rheumatoid arthritis than Rheumatoid factor?


ACPA positive patients tend to have more sever and erosive disease,


Anti-neutrophilic cytoplasmic antibodies (ANCA) were first described as an autoantibody specific for what disease?

Wegeners granulomatosis

(AKA Granulomatosis with polyangiitis)

Also associated with:
Microscopic polyangiitis and churg-strauss syndrome


What ANCA associated systemic vascultidies causes alveoral haemorrhage?

All 3 :
Wegener's granulomatosis
Microscopic polyangiitis
Churg-Strauss syndrome


How useful is ANCA testing ?

- a positive ANCA is useful in suggesting the diagnosis
- a negative ANCA does not exclude AASV (ANCA associated systemic vasculitidies)


What antibody is specific for primary biliary sclerosis?

Anti-mitochondrial antibody


In what disease is anti smooth muscle and anti liver/kidney antibodies found in?

Autoimmune hepatitis


What types of autoantibodies are present in type 1 diabetes?

1) Islet cell antibodies
2) Anti-GAD65 and Anti-GAD67
3)insulin autoantibodies (IAAs)
4) Anti-insulinoma antigen

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