Flashcards in Diagnosis of HIV pts Deck (96)
What is the difference between primary prophylaxis and secondary?
Primary - do not have disease, but prevent from getting
Secondary = have it, but prevent recurrence
Do you use primary prophylaxis for CMV?
What is the prognosis for late diagnosis of HIV?
10-30 years of life loss
What fraction of new HIV diagnoses also have AIDS?
What is the prognosis for HIV pts diagnosed early and have regular treatment?
normal life expectancy
What is the most common AIDS defining illness?
How do you check for toxoplasmosis infx?
What is the CD4 count at which you start secondary prophylaxis for CMV?
Less than 100
What are the components of the HAART therapy?
2 NRTIs + a protease inhibitor or NNRTI
What are the goals of HIV treatment? (3)
-Suppress HIV replication
-Improve immune system
What is the MOA of enfuvirtide?
What is the MOA of maraviroc?
Prevents attachment of HIV to CCR5
What is the suffix for the protease inhibitors for HIV?
What is the caveat for prescribing abacavir?
Need to test HLA-b5701. If have, then will have hypersensitivity reaction to the drug
What is IRIS? What is the treatment for this?
"Immune reconstitution inflammatory syndrome"--inflammatory disorder that occurs with sudden drop of viral load d/t HIV therapy
Usually self limiting, but may prescribe glucocorticoids if bad
What type of HIV drugs have a high incidence of drug-drug interactions? Why?
Protease inhibitors d/t p450 inhibition
True or false: HIV increases the risk of dyslipidemia
True or false: HIV increases the risk of CV disease
True or false: HIV increases the risk of squamous cell CA of the anus
What is the metabolic syndrome that can be caused by HIV drugs?
Cushing like features, but with fat atrophy in the face
What is the anal CA that HIV pts are susceptible to?
Anal warts in an an AIDs pt should be suspicious for what?
Do you need to have anal sex to develop HPV-related anal cancer?
What is the CD4 count at which you would begin prophylaxis for Cryptococcosis?
What is the CD4 count at which you would begin prophylaxis for Histoplasmosis?
What are the integrase inhibitors?
What is the fusion inhibitor?
What are the two major NNRTIs?
What type of drug is zidovudine?