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Flashcards in Diagnosis of HIV pts Deck (96)
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61

What is the difference between primary prophylaxis and secondary?

Primary - do not have disease, but prevent from getting

Secondary = have it, but prevent recurrence

62

Do you use primary prophylaxis for CMV?

No

63

What is the prognosis for late diagnosis of HIV?

10-30 years of life loss

64

What fraction of new HIV diagnoses also have AIDS?

1/3

65

What is the prognosis for HIV pts diagnosed early and have regular treatment?

normal life expectancy

66

What is the most common AIDS defining illness?

Pneumocystis pneumonia

67

How do you check for toxoplasmosis infx?

IgG antibody

68

What is the CD4 count at which you start secondary prophylaxis for CMV?

Less than 100

69

What are the components of the HAART therapy?

2 NRTIs + a protease inhibitor or NNRTI

70

What are the goals of HIV treatment? (3)

-Suppress HIV replication
-Improve immune system
-Prevent transmission

71

What is the MOA of enfuvirtide?

Prevents fusion

72

What is the MOA of maraviroc?

Prevents attachment of HIV to CCR5

73

What is the suffix for the protease inhibitors for HIV?

"-navir"

74

What is the caveat for prescribing abacavir?

Need to test HLA-b5701. If have, then will have hypersensitivity reaction to the drug

75

What is IRIS? What is the treatment for this?

"Immune reconstitution inflammatory syndrome"--inflammatory disorder that occurs with sudden drop of viral load d/t HIV therapy

Usually self limiting, but may prescribe glucocorticoids if bad

76

What type of HIV drugs have a high incidence of drug-drug interactions? Why?

Protease inhibitors d/t p450 inhibition

77

True or false: HIV increases the risk of dyslipidemia

True

78

True or false: HIV increases the risk of CV disease

True

79

True or false: HIV increases the risk of squamous cell CA of the anus

True

80

What is the metabolic syndrome that can be caused by HIV drugs?

Cushing like features, but with fat atrophy in the face

81

What is the anal CA that HIV pts are susceptible to?

HPV-related

82

Anal warts in an an AIDs pt should be suspicious for what?

HPV cancer

83

Do you need to have anal sex to develop HPV-related anal cancer?

No

84

What is the CD4 count at which you would begin prophylaxis for Cryptococcosis?

100

85

What is the CD4 count at which you would begin prophylaxis for Histoplasmosis?

150

86

What are the integrase inhibitors?

"-gravirs"

87

What is the fusion inhibitor?

Enfuvirtide

88

What are the two major NNRTIs?

Nevirapine
Efavirenz

89

What type of drug is zidovudine?

NRTI

90

What type of drug is lamivudine?

NRTI