Flashcards in Dpp4 inhibitors Deck (13):
How does a dpp4 inhibitor med work
Inhibits enzyme that inactivates glp1
Prolong lofe of glp1 which increases insulin, reduces glucagon, slows hastric emptying, reduces food intake
Name the two brand ddp4 drugs
Sitagliptin (januvia) details
100 mg daily
Saxagliptin (onglyza) details
2.5-5 mg daily
Which produces greater weight loss effects
Do you need food to take?
With or without
What to do if patient has renal failure
Sitagliptin- reduces to 50 mg daily if Cr 30-50
Reduce to 25 if Cr less than 30
Saxagliptin- reduces to 2.5 if Cr
Category B, no nursing
No studied in kids
Combo of ddp4 inhibitors and sulf?
Sulf reduces to prevent hypos
What effect can ddp4 inhibitors sitaglupin (januvia) have in pancread
Serious allergic reaction (steven johnson, angioedema, anaphylaxis)
Upper respiratory infection
What should you monitor with increasing doses of sitagliptin (januvia)?