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Flashcards in Dpp4 inhibitors Deck (13):
1

How does a dpp4 inhibitor med work

Inhibits enzyme that inactivates glp1
Prolong lofe of glp1 which increases insulin, reduces glucagon, slows hastric emptying, reduces food intake

2

Name the two brand ddp4 drugs

Sitagliptin (januvia)
Saxagliptin (onglyza)

3

Sitagliptin (januvia) details

100 mg daily
Once daily

4

Saxagliptin (onglyza) details

2.5-5 mg daily
Once daily

5

Which produces greater weight loss effects

Glp1

6

Do you need food to take?

With or without

7

What to do if patient has renal failure

Sitagliptin- reduces to 50 mg daily if Cr 30-50
Reduce to 25 if Cr less than 30
Saxagliptin- reduces to 2.5 if Cr

8

Pregnancy?

Category B, no nursing
No studied in kids

9

Combo of ddp4 inhibitors and sulf?

Sulf reduces to prevent hypos

10

What effect can ddp4 inhibitors sitaglupin (januvia) have in pancread

Pancreatitis

11

Side effects?

Serious allergic reaction (steven johnson, angioedema, anaphylaxis)
Hypersensitivity reactiona
Upper respiratory infection
Headache
Uti

12

What should you monitor with increasing doses of sitagliptin (januvia)?

Pancreatitis

13

Besides pancreatitis monitoring with januvia increase, what should be monitored with general ddp4 increase?

Kidney function, Cr