Flashcards in Amylin analog Deck (15):
What drug is an amylin analog?
How does amylin work naturally in the body?
Produced and co secreted with insulin in response to food intake
How does amylin work in type 1 and tyoe 2 diabetics?
T1 and t2 dm whi require insulin, amylin is dimished d/t pancreatic beta cell dysfunction
Details of pramlintide (symlin) for t1 dm?
15-60 mcg before meals
Titrate up 15 mcg until nausea tolerated
Details of pramlintide (symlin) for t2dm?
60-120 mcg before meals
Why does amylin help lower bg?
Decreases side of post meal bg by:
Slowing gastic emptying
Reducing total caloric intake
Is symlin injection or pill?
What other med can you take if you are t2 dm??
Mist this be given alongside insulin?
Can symlin be mixed with insulin?
Symlin duration of action
Half life 48 minutes to 3 hour duration after injection
Where is symlin metabolized
Kidney failure doesny alter clearance
Why can symlin cause hypo
Secondary effect of making insulin more effective
Descrive gi effects of symlin
Gastroparesis d/t slow hastric emptying.
This means symlin should not be taken with alpha glucosidase inhibitors or anticholinergic agents