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Flashcards in Amylin analog Deck (15):
1

What drug is an amylin analog?

Pramlinitide (symlin)

2

How does amylin work naturally in the body?

Produced and co secreted with insulin in response to food intake

3

How does amylin work in type 1 and tyoe 2 diabetics?

T1 and t2 dm whi require insulin, amylin is dimished d/t pancreatic beta cell dysfunction

4

Details of pramlintide (symlin) for t1 dm?

15-60 mcg before meals
Titrate up 15 mcg until nausea tolerated

5

Details of pramlintide (symlin) for t2dm?

60-120 mcg before meals

6

Why does amylin help lower bg?

Decreases side of post meal bg by:
Slowing gastic emptying
Supressing glucagon
Reducing total caloric intake
Increased satiety

7

Is symlin injection or pill?

Injection

8

What other med can you take if you are t2 dm??

Sulf met

9

Mist this be given alongside insulin?

Yes

10

Can symlin be mixed with insulin?

Never

11

Symlin duration of action

Half life 48 minutes to 3 hour duration after injection

12

Where is symlin metabolized

Kidney
Kidney failure doesny alter clearance

13

Why can symlin cause hypo

Secondary effect of making insulin more effective

14

Descrive gi effects of symlin

Gastroparesis d/t slow hastric emptying.
This means symlin should not be taken with alpha glucosidase inhibitors or anticholinergic agents

15

Biggest side effect

Nauses
48%
Decreases with time
Need fradual titration
Anorecia, vomit, fatigue, headache