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Flashcards in GLP 1 Deck (16):
1

How do incretin based therapies work?

Following a meal, gut hormones are released causing:
1) promption of satiety on brain
2) slow gastric emptying
3) increased insulin realse from beta cella
4) decreased glucagon release from alpha cells

2

What gut hormones are released when you eat?

GIP- glucose dependent insulinotropic peptide
GLP1- glucagon like peptide 1

3

How long does glp1 last before ddp4 inhibits it?

1-2 minutes

4

Name the glp1 receptor agonists

Extenatide (byetta or bydrueon)
Liraglutide (victoza)
Albiglutide (tanzeum)
Dulglutide (trulicity)

5

Exenatide (byetta) details

5-10 mcg
Twice daily
1 hour before meals

6

Liraglutide (victoza)

.6-1.8 mg increased by .6 weeklu
Once daily
Any time
Endogenously metabolized, no specific organ

7

Albiglutide (tanzeum)

30-50 mg
Once weekly

8

Dulglutide (trulicity)

.75-1.5 mg
Once weekly

9

Exenatide (bydureon)

2mg
Once weekly

10

Can you continue using other meds aith glp1?

Ges
Insulin, met, sulf

11

How us exenatide eliminated from the body?

Kidneys
Not recommended in severe renal impairment Cr

12

Shpuld caution be used with absorption of other meds?

Yes
Digoxin, lisinopril, lovastatin, acetaminophen

13

Thyroid cancer in glp1

Caution with byduroen, trulicitu, victoza tanzeum

14

Gl1p contraindications

Thyroid cancer
Gastic disease
T1dm dka

15

Side effecta

Nausea, vd, headache

16

What should patients be monitored once full doses are acheived

Pancreatitia
Thyroid cancer