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Flashcards in Meglitinides Deck (14):
1

Name the two drugs and the Meglinitides drug class

Repaglinide (prandin)
Nateglinide (starlix)

2

What is the brand name of repaglinide

Prandin

3

What is the brand name of nateglinide

Starlix

4

What is the mechanism of action for the meg group

Increase insulin secretion from the pancreas

5

Would you want to combine a sulfonylurea and a meg

No, there is no benefit and Meg should not be used in patients who previously experienced primary or secondary failure of a sulfonylurea

6

Who is the primary candidate for repaglinide

Type 2 diabetic
without dyslipidemia
with or without renal failure
normal weight
fasting plasma glucose greater than 20 points above the target number

7

Who was the primary candidate for a nateglinide medication

Type 2 diabetic with capacity for insulin production is hyperglycemia is not adequately controlled by nutrition or physical activity and it was not been treated long term with other oral glucose lowering agents

8

What is the dose for prandin

.5 to 1 milligrams 3 times per day
Up to 16 milligrams daily, take 3 times per day before meals. Initiated at low doses. Rapid absorption.
Initial dose is usually around 1-2 mg

Can be adjusted weekly

9

What is the dose for starlix

60 - 120 milligrams 3 times per day before meals, up to 360 milligrams daily.
120 is the initial and maintenance dose. 60 for those with controlled a1c

10

How does meg work

Rapid acting oral and insulin ssecretagoguee
that stimulates insulin secretion when needed postprandially and then allows insulin concentrations to return to normal

11

Are meglinitides used for pregnancy

No, and not for breastfeeding or children

12

Caution for taking prandin

Imperative how to function, elderly, debilitated, malnourished, adrenal pituitary hepatic insufficiency, hypoglycemia effects

13

Contraindications of meglonitides

Type 1 diabetes, ketoacidosis, severe stress, severe infection, trama, surgery

14

What is the most common side effect o meglinitides

Hypoglycemia